Lesson 33 - Ion Fragments and chemical formulae II - LCMS

LCMS

Liquid Chromatography-Mass Spectrometry, an analytical technique combining liquid chromatography and mass spectrometry for analyzing complex mixtures.

HPLC

High Performance Liquid Chromatography, a technique in analytical chemistry used to separate, identify, and quantify components in a mixture.

Electrospray Ionization (ESI)

An ionization technique used in mass spectrometry where a high voltage is applied to a liquid to produce an aerosol.

Atmospheric Pressure Chemical Ionization (APCI)

A soft ionization technique used in tandem with liquid chromatography that operates at atmospheric pressure.

Fragment Ions

Ions derived from the breakup of a larger ion during the ionization process in mass spectrometry.

Pharmacokinetics

The study of how drugs move through the body, including absorption, distribution, metabolism, and excretion.

Molecular Ion

An ion formed from a free radical of a molecule, retaining its original molecular weight.

Peptide Mapping

A technique used in characterizing peptides through mass spectrometry based on their mass and sequence.

Molecular Mass

The mass of a molecule, typically expressed in daltons (g/mol) based on the sum of its constituent atoms.

Mass-to-Charge Ratio (m/z)

The ratio of the mass of an ion to its charge, crucial for identifying ions in mass spectrometry.

Ginsenoside Rb1

A specific type of ginsenoside, a saponin compound found in ginseng, with various biological activities.

Negative Ion Fragmentation

The process where negative ions are generated for qualitative and quantitative analysis in mass spectrometry.

Bioaffinity Screening

A method used in drug development to assess the interactions between potential drug candidates and biological targets.

Degradant Identification

The process of detecting and characterizing the breakdown products of a drug compound.

Quantitative Bioanalysis

The quantitative measurement of drugs in biological samples, essential for pharmacokinetic studies.

Natural Products Dereplication

The process of identifying previously known natural products in biological extracts to prioritize novel discoveries.