Compounding Lab Chapter 18 19 31

Which is a route of administration for suppositories?

All of the above are correct.

Which is not an advantage of rectal administration of suppositories?

Rectal absorption is unpredictable.

The major components of the suppository base are

both paraffin wax and fatty acid base are correct

What factor(s) influence(s) bioavailability of rectal administration of suppositories?

All of the above are correct.

Which is not a step in how to insert and use suppositories via the rectal route?

Before inserting suppository, do not empty bowels.

An advantage of vaginal administration of inserts is that

if needed, the dose can be retrieved

Suppositories only provide local activity.

False

An ideal suppository base should be _________________

all of the above are correct

Which of the following is (are) used commonly in suppository bases?

All of the above are correct.

An LVP plastic bag has a protective covering to keep ____

Dust

Air is generally injected into a vial before a volume of solution is removed to ____________.

help withdraw the solution by pressurizing the vial

To ensure that a syringe and needle will deliver a correct volume of liquid,

fill the syringe, hub, and needle with liquid and remove all air bubbles

A lyophilized drug packaged in a vial is added to an LVP solution by ____________.

reconstituting the lyophilized drug in the vial and injecting it to the LVP

Which is not true when performing aseptic technique?

The LAFW is only cleaned at the beginning and end of a shift

Which is not appropriate for cleanroom attire?

Jewelry on the hands or wrists

Compounding of CSPs is to occur in an ISO Class 5 PEC environment. Which PEC can provide such an air quality environment?

All of the above are correct.

When garbing to compound CSPs, the first step you should take is?

put on shoe covers and hair bonnet

Maintaining a laminar airflow inside a PEC is essential when preparing CSPs. The unidirectional airflow pattern can be easily disrupted. Which can potentially disrupt the airflow pattern?

All of the above are correct.

When making hard lozenges, all preparation instructions must be followed carefully, with particular attention to temperatures.

True

Chocolate base lozenges do not need to be overfilled in a troche mold, whereas PEG base lozenges need to be overfilled.

True

Lozenges would not be appropriate to use in

a drug unstable in high temperature

Where should you start to pour the warm preparation when filling a lozenge mold?

B3

The consistency of soft sticks is determined by

all of the above are correct

In order to stiffen a medication stick, you want to add more

high melting point ingredients

A hard medication stick must be moistened to be “activated.”

True

When packaging a medication stick, you want to pour the mixture as soon as you remove the mixture from heat to prevent drug settling in the beaker.

False

Because lozenges and medication sticks are considered nonaqueous preparations, a beyond-use date is not later than the time remaining until the earliest expiration date of any ingredient or API or ______, whichever is earlier.

6 months

What is evidence of instability in lozenge and medication stick preparations

All of the above is correct