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Transmission
Invasive , Ingestion
Medium
Cold Enrichment Medium
Faculative: Anaerobic & Intracellular
Risk
Pregnant woman
Immunocompress
Kidney transplant
Ingestion: milk , soft cheese , undercooked meat
V.F.
Internalins A&B : Cadherin
Listerolysin O : after phagolysosome
Act A : Actin Filaments form Flagella
Filopods
Siderophores
Target
Epithelial cells
Macrophage
Hepatocyte
Pathogenisis
Meningoencephalitis
Granulomatosis Infantiseptica (self-limited)
Meningitis: after kidney transplant
Listeriosis
TX
Ampicillin