Top 300 Drugs Spring 2023 (PURPLE PAIN DRUGS)

Morphine sulfate

Brand names

Morphine sulfate

Brand names

Kadian, Morphabond ER, MS Contin

Morphine sulfate

Drug class

opioid agonists

Morphine sulfate

Approved drug uses

pain, moderate to severe

Morphine sulfate

Normal adult dose

see chart on card-dose varies

Morphine sulfate

Black box warnings

-high abuse potential
-may lead to dependency
-respiratory depression may occur even at accepted dosing
-adverse CV events and death reported on misuse

Allopurinol

Brand names

Zyloprim

Allopurinol

Drug class

xanthine oxidase inhibitor

Allopurinol

Approved drug uses

hyperuricemia, gout prophylaxis

Allopurinol

Normal adult dose

200-600 mg/d divided qD-QID

Allopurinol

Black box warnings

none

Oxycodone

Brand names

Oxycontin, Roxicodone, Xtampza ER

Oxycodone

Drug class

opioid agonists

Oxycodone

Approved drug uses

pain, moderate to severe

Oxycodone

Normal adult dose

individualized dosing

Oxycodone

Black box warnings

-high addiction/misuse risk
-opioid analgesic REMS
-life threatening respiratory depression can occur
-concomitant use with BZDP

Tramadol

Brand names

ConZip, Qdolo

Tramadol

Drug class

Opioid agonists

Tramadol

Approved drug uses

pain, moderate to moderate-severe

Tramadol

Normal adult dose

50-100 mg PO q4-6hr

Tramadol

Black box warnings

-high addiction/misuse risk
-opioid analgesic REMS
-life threatening respiratory depression can occur
-concomitant use with BZDP

Hydrocodone + acetaminophen

Brand names

Lortab, Norco

Hydrocodone + acetaminophen

Drug class

opioid combinations, narcotic + non-narcotic

Hydrocodone + acetaminophen

Approved drug uses

pain, moderate to severe

Hydrocodone + acetaminophen

Normal adult dose

2.5-10 mg hydrocodone PO q4-6hrs prn

Hydrocodone + acetaminophen

Black box warnings

Avoid doses of APAP >4000 mg per day (associated with cases of acute liver failure)

Butalbital + APAP

Brand names

Fioricet, Allzital, Bupap, Phrenilin, Phrenilin Forte

Butalbital + APAP

Drug class

pain reliever and relaxant combination

Butalbital + APAP

Approved drug uses

headache, migraine headache

Butalbital + APAP

Normal adult dose

1-2 PO q4hrs prn

Butalbital + APAP

Black box warnings

Avoid doses of APAP >4000 mg per day (associated with cases of acute liver failure)

Colchicine

Brand names

Colcrys, Gloperba, Mitigare

Colchicine

Drug class

Anti-gout

Colchicine

Approved drug uses

treatment and prevention of gout

Colchicine

Normal adult dose

0.6 mg PO qD/BID

Colchicine

Black box warnings

none

Ketorolac

Brand names

Toradol, Toradol IM/IV, Sprix

Ketorolac

Drug class

non-steroidal anti-inflammatory drugs (NSAIDs)

Ketorolac

Approved drug uses

moderate to severe pain, migraine headaches

Ketorolac

Normal adult dose

10 mg PO q4-6hr prn

Ketorolac

Black box warnings

-Oral: up to 5 days tx and only after parenteral use
- all:
may increase risk of CV thrombotic events
may increase risk of fatal GI events
GI bleeding, ulceration, and proliferation

Diclofenac

Brand names

Voltaren, Voltaren XR- topical
Cambia, Catafiam-tablets

Diclofenac

Drug class

non-steroidal anti-inflammatory drug (NSAID)

Diclofenac

Approved drug uses

osteoarthritis, rheumatoid arthritis

Diclofenac

Normal adult dose

DR: 50 mg PO BID-TID
ER: 100 mg PO qD

Diclofenac

Black box warnings

-may increase risk of CV thrombotic events
-may increase risk of fatal GI events
-GI bleeding, ulceration, and proliferation

Celecoxib

Brand names

Celebrex

Celecoxib

Drug class

COX-2 inhibitor, NSAID

Celecoxib

Approved drug uses

osteoarthritis, rheumatoid arthritis, dysmenorrhea, pain

Celecoxib

Normal adult dose

100-200 mg PO qD-BID

Celecoxib

Black box warnings

-may increase risk of CV thrombotic events
-may increase risk of fatal GI events
-GI bleeding, ulceration, and proliferation

Naproxen

Brand names

Naprosyn, EC-Naprosyn, Naprelan

Naproxen

Drug class

nonsteroidal anti-inflammatory drug (NSAID)

Naproxen

Approved drug uses

osteoarthritis, rheumatoid arthritis

Naproxen

Normal adult dose

IR/DR: 250-500 mg PO q12hr
ER: 750-1000 mg PO qD

Naproxen

Black box warnings

-may increase risk of CV thrombotic events
-may increase risk of fatal GI events
-GI bleeding, ulceration, and proliferation

Meloxicam

Brand names

Mobic

Meloxicam

Drug class

Nonsteroidal Anti-inflammatory Drugs (NSAID)

Meloxicam

Approved drug uses

osteoarthritis, rheumatoid arthritis

Meloxicam

Normal adult dose

7.5-15 mg PO qD

Meloxicam

Black box warnings

-may increase risk of CV thrombotic events
-may increase risk of fatal GI events
-GI bleeding, ulceration, and proliferation

Ibuprofen

Brand names

Advil, Motrin IB

Ibuprofen

Drug class

Nonsteroidal Anti-inflammatory Drug (NSAID)

Ibuprofen

Approved drug uses

fever, pain, osteoarthritis, rheumatoid arthritis

Ibuprofen

Normal adult dose

Peds: 5-10mg/kg q6-8hrs
Adult: 300 mg-800 mg TID-QID

Ibuprofen

Black box warnings

-may increase risk of CV thrombotic events
-may increase risk of fatal GI events
-GI bleeding, ulceration, and proliferation