Behavior Modifying Drugs (Flashcards from Canvas)

serotonin

The major neurotransmitter targeted for behavior modifying drugs

5-HT (1-5)

The receptor type targeted by behavior modifying drugs that act on serotonin

Norepineprhine, epinephrine

These catecholamines may also be targeted by behavior modifying drugs

F (most result in stimulatory actions even though their mechanism of action is to inhibit reuptake)

Most behavior modifying drugs are inhibitory in terms of pharmacodynamic response: True or False

GABA (gamma amino butyric acid).

Of the neurotransmitters targeted by CNS drugs, the one that is most likely to be inhibitory in nature

separation anxiety

The abnormal behavior indicated for behavior modifying drugs approved for use in dogs or cats.

Tolerance and physical dependence (which may lead to withdrawal)

Adaptation of the brain to behavior modifying drugs may result in these to phenomena

tolerance

The term used to refer to the need for higher drug concentrations to produce the same response

Physical dependance

The term used to refer to the state in which rapid discontinuation of a drug may lead to clinical signs of withdrawal

obsessive compulsive disorders, urinary spraying

A common, extralabel indication for behavior modifing drugs in dogs and cats.

tranquilizers

Drugs which induce sedation or calmness without sleep

neuroleptics

Tranquilizers which alter behavior or response to environment

dopamine-2

The receptors targeted by tranquilizers

low

Acepromazine is a high or low potency tranquilizer (choose one)?

alpha (1 more than 2)

Non-dopamine receptors targeted (blocked) by acepromazine that may cause hypotension

histamine

Non-dopamine receptors targeted (blocked) by acepromazine that contribute to sedation

its controversial

Phenothiazines worsen seizures: yes, no or its controversial

aggression

This behavior may be worsened by acepromazine

anxiety

The sole behavior disorder for which acepromazine might be used to treat in animals

T

Antidepressants are CNS stimulants: true or false

Tri-cyclic antidepressants

Clomipramine belongs to what class of behavior modifying drug?

serotonin

The primary neurotransmitter targeted by clomipramine

Time to steady-state, CNS adaptation

Two reasons why the effects of behavior modifying drugs may be characterized by a lag time.

Physical dependance

Drugs with a short half-life should not be rapidly discontinued because of this concern.

F

The dose of behavior modifying drugs is generally the same among most species: True or False

metabolites are active

This characteristic balances the potential disadvantage of first pass metabolism

half-life that is longer than the parent

This characteristic of metabolites often results in longer duratio nof effect of a drug

about 9 hrs

the half-life of clomipramine and its metabolite in dogs

clomipramine, fluoxetine

A drug approved for use in dogs to treat separation anxiety

Large, indeed, very large.

The volume of distribution of behavior modifying drugs is large or small? Choose one

cardiovascular

Side effects of TCA in general, but less so for clomipramine, because autonomic receptors are targeted

seizures

All CNS stimulants increase the risk of this adversity

Selective serotonin re-uptake inhibitor

The class of drugs to which fluoexitine belongs

about 6 hrs

The half-life of fluoxetine in dogs

about 50 hrs

The half-life of norfluoxetine in dogs

35 hrs

The half-life of fluoxetine in cats

about 2 weeks

The lag time that characterizes fluoxetine

T

Behavior modifying drugs are generally subject to the impact of drug metabolizing enzyme inducers or inhibitors: true or false

fluoxetine, trazodone

This behavior modifying drug may inhibit drug metabolizing enzymes

trazodone

A behavior modifying drug whose extralabel indication is anxiety in intensive care

monoamine oxidase inhibitor, B

The mechanism of action of deprenyl (seligiline)

dopamine

The target neurotransmitter for cognitive disorders associated with geriatric dementia

dexmedetomidine

Avaialble in gel form for treatment of noise phobias

the former is the dex enantiomer of the latter

The relationship between dexmedetomidine and metomidine

Transmucosal

The route of administration of dexmedetomidine gel

alpha 2 agonist

The mechanism of action of dexmedetomidine