Pediatric Oncology: Common Chemotherapy Drugs and Adverse Effects
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What is the most common chemotherapy drug used for pediatric brain tumors?
Vincristine (brain)
What are the major adverse effects of Vincristine?
Peripheral neuropathy, constipation, jaw pain, SIADH, no myelosuppression.
What is the most common chemo drug used for ALL (CNS prophylaxis + maintenance)?
Methotrexate
What are the major adverse effects of Methotrexate?
Hepatotoxicity, myelosuppression, mucositis, nephrotoxicity, photosensitivity.
What is the most common chemo drug for Wilms tumor?
Vincristine
What is the most common chemo drug used for neuroblastoma?
Cyclophosphamide
What is a major adverse effect of Cyclophosphamide?
Hemorrhagic cystitis
What are other effects of Cyclophosphamide?
Myelosuppression, nausea, alopecia.
What is the most common chemo drug used for osteosarcoma?
Doxorubicin
What are the major adverse effects of Doxorubicin?
Cardiotoxicity, red/orange urine, myelosuppression.
What is the most common chemo drug for retinoblastoma?
Carboplatin
What are the major adverse effects of Carboplatin?
Myelosuppression, ototoxicity, nephrotoxicity, nausea.
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