Role of Sema3A and Nrp1 in Neuronal Mapping

What is the role of olfactory receptors in glomerular mapping?

Olfactory neurons of the same type express the same unique receptor and send their axons to the same glomerulus.

How do mutant axons organize in relation to sema-3A and Nrp-1?

Some axons have high levels of sema-3A while others have high levels of Nrp-1, which helps them organize.

What are the three types of dendrites in neurons?

Basal (don't extend far), Proximal (close to cell body), and Apical (extend far away).

What is the function of dendritic arborization?

Dendritic arborization is involved in signal reception, integration, and transmission to the cell body.

What intrinsic factor is expressed by Class I neurons in Drosophila?

Abrupt (Tf) is expressed by Class I neurons.

What happens to dendrites in an abrupt mutant?

In an abrupt mutant, dendrites become more complex and symmetrical.

What environmental factor promotes dendrite formation in vitro?

Sema3A promotes the formation of dendrites.

What is the effect of inhibiting Nrp1 on dendrite formation?

Inhibiting Nrp1 results in spontaneous random dendrite formation.

What is the role of motor proteins like Dynein and Lis1 in neurons?

They are involved in cytoskeletal growth, branching, and guidance.

What is the secretory pathway's role in neuronal development?

The secretory pathway regulates local protein synthesis, which is crucial for neuronal growth and branching.

What is the process of self-avoidance in axonal branching?

Self-avoidance is the process by which branches of an axonal arbor or dendrites from a single neuron avoid overlapping with one another.

Which protein regulates self-avoidance in neurons?

DSCAM regulates self-avoidance and is necessary for this process in flies.

What are some guidance molecules involved in axon growth?

Sema3A, Ephrins, Slits, Wnt, BDNF, Integrins, and BMP-7.

What is the significance of tiling in neuronal development?

Tiling is the process that ensures that axonal branches do not overlap, allowing for organized neural circuits.

How do intrinsic factors influence dendritogenesis?

Different neuron classes have distinct transcriptional regulations for dendritogenesis.

What is the relationship between activity levels and dendrite formation?

Dendrite formation can be influenced by the activity level of the neuron.

What is the effect of sema3A on dendritic development in the stripe assay experiment?

Sema3A promotes the formation of dendrites in vitro during the stripe assay.

What is the role of local protein synthesis in neurons?

Local protein synthesis is crucial for growth and guidance during neuronal development.

What are the transcription factors involved in dendritogenesis?

Cut and Knox are transcription factors involved in dendritogenesis.

What is the significance of the environmental factors in dendritogenesis?

Environmental factors, such as sema3A, can significantly influence the development and complexity of dendrites.

What is the relationship between [cAMP] levels and Nrp1/Sema3A expression?

High [cAMP] levels correlate with low Nrp1 transcription and high Sema3A levels, while low [cAMP] levels correlate with high Nrp1 transcription and low Sema3A levels.