Glycolysis and TCR steps

What step is this and what are the products and reactants

Step 1: Glucose + ATP → Glucose-6-phosphate + ADP

What enzyme goes with this reaction

Hexokinase

What step is this and what are the products and reactants

Step 2: Glucose-6-phosphate → Fructose-6-phosphate

What enzyme goes with this reaction

Glucose phosphate isomerase

What step is this and what are the products and reactants

Step 3: Fructose-6-phosphate + ATP → Fructose-1,6- biphosphate + ATP

What enzyme goes with this reaction

Phosphofructokinase

What step is this and what are the products and reactants

Step 4: Fructose-1,6-biphosphate → Dihydroxyacetone phosphate + Glyceraldehyde-3-phosphate

What enzyme goes with this reaction

Aldose

What step is this and what are the products and reactants

Step 5: Dihydroxyacetone phosphate → Glyceraldehyde-3-phosphate

What enzyme goes with this reaction

Triose phosphate isomerase

What step is this and what are the products and reactants

Step 6: 2(Glyceraldehyde-3-phosphate + NAD+ +Pi → 1,3-biphosphoglycerate + NADH + H+)

What enzyme goes with this reaction

Glyceraldehyde-3-Pdehydrogenase

What step is this and what are the products and reactants

Step 7: 2(1,3-biphosphoglycerate + ADP → 3-phosphoglycerate + ATP)

What enzyme goes with this reaction

Phosphoglycerate Kinase

What step is this and what are the products and reactants

Step 8: 2(3-phosphoglycerate → 2-phosphoglycerate)

What enzyme goes with this reaction

Phosphoglyceromutase

What step is this and what are the products and reactants

Step 9: 2(2-phosphoglycerate → Phosphoenolpyruvate + H2O)

What enzyme goes with this reaction

Enolase

What step is this and what are the products and reactants

Step 10: 2(Phosphoenolpyruvate + ADP → Pyruvate + ATP)

What enzyme goes with this reaction

Pyruvate Kinase

TCA Cycle: Pre-step

Formation of acetyl-CoA

TCA Cycle: Step 1 reaction/enzyme

Formation of Citrate from Acetyl-CoA and Oxaloacetate

• Acetyl-CoA + Oxaloacetate + H2O → Citrate + CoA-SH

• Citrate synthase

TCA Cycle: Step 2 reaction/enzyme

Isomerization of Citrate to Isocitrate

• Citrate → Isocitrate

• Aconitase

TCA Cycle: Step 3 reaction/enzyme

Formation of α-ketoglutarate and release of CO 2 /NADH

• Isocitrate dehydrogenase step is the main rate-limiting step

• Isocitrate + NAD+ → α-ketoglutarate + NADH + CO2 + H+

TCA Cycle: Step 4 reaction/enzyme

Formation of Succinyl-CoA and release of CO2 /NADH

• α-ketoglutarate + NAD+ + CoA-SH → Succinyl-CoA + NADH + CO2 + H+

• α-ketoglutarate dehydrogenase

TCA Cycle: Step 5 reaction/enzyme

Formation of Succinate and release of GTP

• Succinyl-CoA + GDP + Pi → Succinate + GTP + CoA-SH

• Succinyl-CoA synthase

TCA Cycle: Step 6 reaction/enzyme

Formation of Fumarate and release of FADH2

• Succinate + FAD → Fumerate + FADH2

• Succinate dehydrogenase

TCA Cycle: Step 7 reaction/enzyme

Formation of Malate

• Fumarate + H2O → L-Malate

• Fumarase

TCA Cycle: Step 8 reaction/enzyme

Regeneration of oxaloacetate and release of NADH

• L-Malate + NAD+ → Oxaloacetate + NADH + H+

• Malate dehydrogenase