Substitution and Elimination Orgo

Nucleophiles (only)

Halides, sulfur nucelophiles

Base (only)

hydrogen negative ion, t-butyl oxide

Strong Nucleophile/Strong Base

HO-, MeO-, EtO-, tert-butoxide

weak base, weak nucleophile

H2O, MeOH, EtOH

Nucleophile only (primary cation)

SN2

Nucleophile only (secondary)

SN2

Nucleophile only (tertiary)

SN1

Base only (primary)

E2

Base only (secondary)

E2

Base only (tertiary)

E2

Strong nucleophile/strong base (primary)

E2, SN2

For Strong nucleophile/strong base (primary) which reaction produces a major product? Which one produces minor product?

SN2: Major, E2: Minor

Strong nucleophile/strong base (secondary)

E2, SN2

For Strong nucleophile/strong base (secondary) which reaction produces major product? Which one produces minor product?

E2: Major, SN2: Minor

Strong nucleophile/strong base (tertiary)

E2

Weak nucleophile/weak base (primary)

SN2, E2

weak nucleophile/weak base (secondary)

SN2, SN1, E2, E1

weak nucleophile/weak base (tertiary)

SN1, E1