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plasma membrane separates
intracellular fluid from extracellular fluid
plasma membrane controls
passage of solutes into and out of the cell
determines whether a solute can cross the membrane
chemistry of the solute and membrane
plasma membrane is made of
proteins and lipids
plasma membrane is a
phospholipid bilayer
phosphate head
hydrophilic
phosphate tail
hyrophobic
phospates have
nitrogen containing group, phosphate group, glycerol, fatty acid tails
saturated fatty acid tails can
pack together tightly making wall stiffer
unsaturated fatty acid tails
double bonds of carbon, can not pack tightly
phospholipid subtypes
make up majority of membrane lipids
glycolipids
protects cells, prevent cell fusion
glycolipids have
short carbohydrate chains on ECF face
cholestreol
reduces membrane fluidity by holding phospholipids still
flippase
flips heads into inside cell
floppase
flips heads into outside cell
scramblease
can put heads to inside and outside of cell
lipid rafts
lipids that gather into rigid patches, can stiffen or create more movement
lipid raft functions
cell signaling;close assembly of effectors, forming caveolae, cytoskeleton anchoring
integral protein
penetrate membrane
transmembrane proteins
pass through plasma pmembrane
hydrophilic regions
contact intracellular fluid and extracellular fluid
hydrophobic regions
pass through plasma membrane
peripheral
do not penetrate membrane, are usually anchored
membrane protein receptors
bind chemical signals
second messenger systems
communicate within cell (relay messages)
enzymes
cell metabolism reactions, addition of chemical groups
channel protein
open or gated
carriers
bind solutes and transfer them across membrane
cell identify markers
glycoproteins act as unique “tag”
cell adhesion molecules
mechanically link cell to another cell or to extracellular material
passive transport
no cellular energy required, solutes go down (with) gradient
active transport
cellular transport is required, solutes go against gradient
passive mechanisms
simple diffusion, osmosis, facilitated diffusion
active mechanisms
vesicular transport, primary active transport (vesicular transport require ATP), secondary active transport (does bot require ATP)
Molecules with nonpolar covalent bonds are
typically hydrophobic
molecules with polar covalent bonds are
typically hydrophilic
transport proteins
channel proteins, gated ion channels, carrier proteins
channel proteins transport solutes via
facilitated diffusion and have specificity
ion movement strongly influences
water movement
osmosis
a specialized form of facilitated diffusion
types of ion channels
voltage gated, chemically gated, mechanically gated
gated ion channels
are quite a stimulus to transport solutes via facilitated diffusion and have specificity
chemically gated
chemical messenger binds to protein and induces opening
when acetylcholine neurotransmitters bind to receptor
it permits passage of Na+ and K+ ions
mechanically gated
mechanical force on cell membrane physically opens channel
carrier proteins transport solutes via
facilitated diffusion or active transport and have specificity
types of active transport proteins
coupled transporters and ATP-driven pumps