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psychosis
-a mental state marked by loss of contact with reality
-involves distorted thoughts, perceptions, and emotions
psychotic disorters
-a group of disorders characterized by psychosis
-common features: irrational ideas, hallucinations, and delusions
schizophrenia spectrum disorder
-complex, serious mental disorder that affects thoughts, emotions, perceptions, and behavior
-"spectrum" refers to the wide variation in how the disorder presents
-symptoms, severity, and course of illness differ from each individual
positive schizo symptoms
-inappropriate behaviors are present
-hallucinations, delusions, disorganized speech, inappropriate laughter/tears/rage
negative schizo symptoms
-appropriate behaviors are absent
-flat affect (absence of emotion/expression, apathy, monotone voice, etc.), reduced speech, mute/rigid body
disturbed perceptions and beliefs
-hallucinations
-delusions
delusions of persecution
belief that one is being targeted/harassed
delusions of grandeur
inflated sense of self-importance or power
delusions of reference
belief that ordinary objects/events have special meanings for oneself
somatic delusions
false beliefs about the body
disorganized speech
-thoughts becoming jumbled, making speech difficult to follow
-word salad
schizophrenia paranoid subtype
-dominated by delusions and hallucinations
-common themes: persecution, grandiosity
-often more organized thought and behavior than other subtypes
schizophrenia catatonic subtype
-marked by abnormal motor behavior
-ranges from motionless rigidity to agitated, repetitive actions
-echolalia and echopraxia: repeating another person's speech or movements like a parrot
subtypes of schizophrenia
-paranoid
-catatonic
onset types of schizophrenia
-chronic (process)
-acute (reactive)
chronic (process)
-develops gradually, typically emerging by late adolescence or early adulthood
-symptoms worsen over time: psychotic episodes last longer, and periods of recovery become shorter
-social withdraws and persistent negative symptoms
-recovery is less common
-more frequently observed in men, who also tend to develop the disorder earlier and display more negative symptoms
acute (reactive)
-can begin at any age with rapid onset
-often triggered by a stressful or traumatic event
-symptoms tend to be dominated by positive symptoms that respond well to treatment
-recovery is more likely compared to chronic onset
brain abnormalities
-dopamine overactivity
-abnormal brain activity
-structural differences
-genetic connection
dopamine overactivity
-linked to positive symptoms
-antipsychotic drugs block dopamine
-stimulants can worsen symptoms
abnormal brain activity
-low activity in frontal lobes (planning, decision-making)
-overactive amygdala (emotional process, especially fear)
-increased thalamus activity during hallucinations (sensory relay center)
structural differences
-enlarged ventricles with surrounding tissue shrinkage
-reduced size in cortex, hippocampus, and corpus callosum
prenatal environment and risk factors
-complications during pregnancy and birth may increase
-the CDC recommends flu shots for pregnant women
-identical twins
prenatal identified risk factors of schizo
-low birth weight
-maternal diabetes
-older paternal age
-oxygen deprivation during delivery
-viral infections during pregnancy
chance of identical twins having schizo
-share a placenta = 60%
-separate placenta = 10%
genetic factors of schizophrenia
-risk increases with genetic closeness
-1 in 10 chance if a parent or sibling has schizo
-genetic influence affects brain development and chemistry
-heredity is a factor, but not the sole cause
environmental triggers
-stressful life events (trauma, abuse, loss) may trigger symptoms
-substance use (cannabis, amphetamines, hallucinogens) linked to psychosis
-social isolation and urban living increase risk
-childhood adversity (poverty, unstable family environments) contribute
-environmental factors interact with genetic/biological vulnerability