Inflammation and Infection

NURS 419

histamine

• major mediator for inflammation

• cause allergic rxns

cutaneous wound healing

• inflammatory phase - starts to hurt

• proliferative phase - cells being made (swelling and pus)

• remodeling phase - keloid formation (skin heals)

antihistamines

• reduce inflammation

• diphenhydramine (benadryl)

• cetirizine (zyrtec)

• loratadine (claritin)

• fexofendene (allegra)

H1 antagonist

• tx mild allergic disorders

• CNS and anticholinergic rxns: SNS

corticosteroids

• anti-inflammatory

• elevate blood glucose

• increase water and sodium retention (hypernatremia)

• lose K+ (hypokalcemia)

• edema

• BP drops

• worry about pt w/ organ transplants and autoimmune disease (on steroids forever)

cox tree inhibitors (NSAIDS, ASA

• suppress inflammation

• relive pain

• reduce fever

• gastric ulceration

• bleeding

• renal impairment

cox tree

• promote inflammation

• stimulate pain

• protect gastric mucosa

• maintain renal blood flow

• mediate fever

ASA

• reduce fever

• decrease inflammation

• salicylism (tinnitus)

• acidic

• prevent clots

• can’t take w/ blood thinners or NSAIDS

NSAIDS

• hurt kidneys

• ibuprofen (advil, motrin)

• celecoxib (celebrex) - has sulfur; can’t give w/ other NSAIDS

acetaminophen (tylenol)

• interfere w/ cox tree

• dont do anything to inflammation

• inhibit prostaglandins

• 4g max daily (4000mg)

• in narcotics

ketorolac (toradol)

• NSAID

• gives lots of relief

• PO, IV, IM