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malignant hyperthermia
malignant hyperthermia
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what is it
psot anaesthetic drugs, caused by excess of Ca2+ release, susceptibility inherited in autosomal dominant
2
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causes
halothane, suxamethonium, antipsychotics
3
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investigations
raised CK, contracture tests with halothane and caffeine
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management
dantrolene which prevents ca2+ release from sarcoplasmic reticulum
5
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presentation
hyperpyrexia, muscle rigidity