Omeprazole - Proton Pump Inhibitors (PPI)

Flashcards covering the key concepts related to Proton Pump Inhibitors (PPI) and specifically omeprazole for pharmacology review.

What are the therapeutic uses of omeprazole?

• Gastric and duodenal ulcers,

• prolonged dyspepsia,

• GERD

• Erosive esophagitis, and

• Hypersecretory disorders like Zollinger-Ellison syndrome.

What are common adverse drug reactions associated with omeprazole?

• Bone loss (long-term use) - can increase risk of osteoporosis.

• Headache, abdominal pain, N/V, diarrhea

• Hypomagnesemia.

What should be monitored during longer-term therapy with omeprazole?

• Bone loss via bone density scanning

• Severe vomiting or diarrhea

• Magnesium levels.

When should omeprazole be administered?

• Once daily before the first meal of the day.

• Do not crush or chew the tablets; swallow whole.

What instructions should be given to clients taking omeprazole?

• Perform weight-bearing exercise daily,

• Consume adequate calcium and vitamin D,

• Report vomiting or diarrhea,

• Drink plenty of clear fluids, and

• Take magnesium supplements as needed.

What are the contraindications for using omeprazole?

• Hypersensitivity

• Concurrent use of rilpivirine (a medication used to treat HIV)

What precautions should be taken when using omeprazole?

• Liver dysfunction and

• Pregnancy and lactation.

What interactions should be noted when using omeprazole?

• Absorption of atazanavir, ketoconazole, and itraconazole decreases

• Food can reduce absorption

• Levels of warfarin, phenytoin, and diazepam increase; St. John’s wort decreases medication levels.