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what is glucose responsible for?
glucose is responsible for keeping your body functional
what is the preferred energy source for the brain?
glucose
what is glycogen responsible for?
responsible for storing glucose
where is glycogen stored?
in the liver or muscles
when is glucose released?
between meals and when glucose levels are low
what is insulin responsible for?
mediating the glucose glycogen balance
what happens to your blood sugar after eating?
increase
what happens when there is an uptake of glucose by cells after eating?
some is used for immediate energy, some is stored as glycogen and the excess is stored as adipose
what happens to your blood sugar as time goes on after eating?
slow decrease in blood sugar
what does the liver convert glycogen into?
glucose
what sensation do you feel when your glycogen levels decrease?
hunger
what is NPY
it is an appitite stimulant and it increases appitite and food seeking behaviors
name some satiety signals
stomach stretch receptors via vagus nerve
gastrointestinal tract secretion of digestive hormones
liver releases glucose
what is CCK stand for
Cholecystikinin
what is CCK
is a hormone responsible for feelings of satiety that come from the small intestine. This serves as a signal to stop eating and is a short term satiety feeling.
what stores long term energy?
fat
how much more energy density does fat have comapred to carbs?
more than twice the amount
how many kcal in 1 g of fat
9 kcal
how many kcal in 1 g of carbs
4 kcal
what is adipose tissue
a fat responsible for secreting a hormone called leptin
what is leptin
responsible for storing long term energy. When lepton is level high, appitite is reduced
what can lack of leptin lead to?
obseity
what is leptin resistance?
beyond regular level, the effect of leptin on appetite has no affect
how did lepton help survival historically?
low lepton levels meant that energy was low, therefore increased foraging activity
what does leptin inhibit?
NPY
what does NPY promote?
carb intake
what are endogenous opiods?
chemical substances that contribute to rewards driven feeding behaviors
what is naloxone?
a drug that reduces intake of saccharin, sucrose and saline
what happens when there is a lack of opioid receptors?
there is a decrease in sacchrin consumption/craving
what source is glucose from
food
where is glycogen sourced from
the liver
where is insulin sourced from
pancreas
where is CCK sourced from?
small intestine
where is NPY sourced from
hypothalamus
where is leptin sourced from?
Adipose
function of glucose
primary fuel
function of glycogen
stores glucose
function of insulin
stimulates glucose metabolism and glycogen synthesis
CCK function
short term satiation
NPY function
stimulates appetite
Leptin Function
high levels inhibit NPY and low levels promote feeding
what tastes are craved most
salty and umami because they indicate safe, nutritious and rich and energy
are females or males more senestive to taste?
females, espeically sensetive to bitterness during pregnancy
function of taste receptor
detects and responds to dissolved food molecules
how many taste receptor cells are on a signle taste bud?
50-150
where are taste receptors located?
on taste buds
how much of the taste buds are located on the tongue
mostt are located on the tongue. 2/3.
where else are the tastebuds located apart from the tongue?
soft palet and throat opening
name the 5 tastes
sweet, salty, bitter, sour and umami
what does sweetness indicate
high energy
what does saltiness indicate
able to digest electrolites
what does sourness and bitterness indicate?
a warning of harm, spoiled or poisonous food
what does umami indicate?
detects amino acids, glutamate and aspertate
where do food molecules go after the taste receptors?
through the gustatory nerve into the medulla
after the medulla, where is next?
thalamus
after reaching the thalamus, where can taste sensation travel to?
either:
hypothalamus + Amygdata or Gustatery cortex then primary somosatory cortex
Guestatory cortex
used to preceive taste, it is connected to other parts of the brain to combine taste with other sensations
what happens when the pathway goes from the Gustatory cortex to the primary somosatory cortex?
taste and texture are combined
what happens when the pathway goes from Gustatory cortex to the orbital cortex?
flavour is preceived because the sensation of taste is combined with smell
what situations would the taste pathway goes to thalamus into the hypothalamus and amygdata?
hormonal feeding patterns, CKK activity and satiety behaviors
what is restronasal smell?
ability to detect flavour
where is flavour processed?
nasopharynx
what happens when we detect spice
the chemical “capsaicin” is released which activates heat and pain receptors
why does smell go straight to the cortex?
smell can alert the events in the enviornment and it essential for survival as it allows you to find food, mates and preds
what happens after molecules eneter the nasal cavity?
the molecules dissolve in mucus
what do the smell molecules do after they have been dissolved
interact with olfactory cilia
where is the olfactory cilia located?
they cover the receptors surface also called the olfactory epithelium
how many cilia does each receptor get info from?
10-20 cilia
what happens after the oderants bind to the recpetoirs?
the receptors fire action potentials and travel along axons to the oldfactory bulb
what happens after the odourants reach the olfactory bulb?
receptors axons synapse with dendrites of glomuli
what do the glomuli do?
send action potentials to higher regions of the brain
what “higher regions of the brain” does the glamaruli send action potentials towards?
the limbic system, primary olfactory cortex and the orbital lobe