Enzyme-Linked Receptors: Receptor Tyrosine Kinases

Receptor Tyrosine Kinases

Enzymes with a single transmembrane domain.

Dimerization

Binding of two receptor subunits together.

Tyrosine Kinase Domain

Intracellular region that phosphorylates tyrosine residues.

Phosphorylation

Addition of phosphate groups to proteins.

Agonist Binding

Activation of receptor upon ligand attachment.

Adapter Proteins

Link RTKs to intracellular signaling pathways.

Insulin Receptor

RTK involved in regulating glucose metabolism.

HER2 Receptor

RTK important for epithelial cell growth.

Cell Growth Regulation

Physiological role of RTKs in cell proliferation.

Cancer Therapeutics

Use of RTKs as drug targets in cancer.

Synthetic Insulin

Pharmaceutical target for receptor tyrosine kinases.

Epithelial Cell Differentiation

Process regulated by HER2 receptor activity.