IPS1 - Introduction - Appearance and Palatability Flavoring of Pharmaceuticals

Proverbs 16:3

● Cinnamon, raspberry, and orange flavors

● Cocoa

● Fruit or citrus flavors

● Organic esters, alcohols, and aldehydes

FLAVORANTS

● Cinnamon

● Raspberry

● Orange

[FLAVORANTS]

____ [3] mask SALTY taste of drugs containing chlorides of sodium, potassium, and ammonium.

salty

[FLAVORANTS]

Cinnamon, raspberry and orange flavors mask ___ taste of drugs containing chlorides of sodium, potassium, and ammonium.

chlorides of sodium, potassium, and ammonium

[FLAVORANTS]

Cinnamon, raspberry and orange flavors mask SALTY taste of drugs containing chlorides of ____

Cocoa

[FLAVORANTS]

This mask the BITTER taste of drugs like ALKALOIDS and EPSOM SALT.

bitter

[FLAVORANTS]

Cocoa mask the ___ taste of drugs like ALKALOIDS and EPSOM SALT.

● Alkaloids

● Epsom salt

[FLAVORANTS]

Cocoa mask the BITTER taste of drugs like ___ [2]

● Fruit flavors

● Citrus flavors

[FLAVORANTS]

These combat ACID or SOUR taste of drugs.

acid or sour

[FLAVORANTS]

Fruit or citrus flavors combat ___ taste of drugs.

● Organic esters

● Alcohols

● Aldehydes

[FLAVORANTS]

These flavorants are pleasant to taste [3]

● Sucrose

● Glycerin

● Saccharin

● Aspartame

● Cyclamate

● Acesulfame Potassium

● Stevia Powder

SWEETENING AGENTS

Sucrose

[SWEETENING AGENTS]

Commonly used sweetener

Sucrose

[SWEETENING AGENTS]

Sweetener from sugar cane/sugar beet

● Sugar cane (Saccharum officinarum)

● Sugar beet (Beta vulgaris)

[SWEETENING AGENTS]

Sources of sucrose [2]

Glycerin

[SWEETENING AGENTS]

Less sweet than sucrose

Saccharin

[SWEETENING AGENTS]

• 300 times as sweet as sucrose

• Has a bitter after taste

Saccharin

[SWEETENING AGENTS]

300 times as sweet as sucrose

Saccharin

[SWEETENING AGENTS]

This has a BITTER aftertaste.

300 times

[SWEETENING AGENTS]

Saccharin is ____ times as sweet as sucrose

Aspartame

[SWEETENING AGENTS]

• 180 to 200 times sweeter than sucrose

• Contraindicated to phenylketonurics

Aspartame

[SWEETENING AGENTS]

180 to 200 times sweeter than sucrose

Aspartame

[SWEETENING AGENTS]

This is contraindicated to phenylketonurics.

180 to 200 times

[SWEETENING AGENTS]

Aspartame is ___ times sweeter than sucrose.

Phenylketonuria

[SWEETENING AGENTS]

Aspartame is contraindicated to ___

Cyclamate

[SWEETENING AGENTS]

This has CARCINOGENIC potential.

Acesulfame potassium

[SWEETENING AGENTS]

130 times as sweet as sucrose.

130 times

[SWEETENING AGENTS]

Acesulfame potassium is ____ times as sweet as sucrose.

Stevia powder

[SWEETENING AGENTS]

Natural, non-toxic, safe and about 30 times sweeter than sucrose

30 times

[SWEETENING AGENTS]

Stevia powder is NATURAL , NON-TOXIC, SAFE and about ___ times sweeter than sucrose

Stevia powder

[SWEETENING AGENTS]

Sweetener used in DIABETIC patients.

● Liquid Dyes

● Lake Pigments

COLORANTS [2]

Liquid dyes

[COLORANTS]

The amount added to liquid preparations ranges from 0.0005 to 0.001% depending upon the colorant and the depth of color desired.

Lake pigments

[COLORANTS]

These are suitable for coloring products in which the moisture levels are LOW.

0.0005% to 0.001%

[COLORANTS]

The amount of LIQUID DYES added to liquid preparations ranges from ____ to ____ depending upon the colorant and the depth of color desired.

FD and C lake

[COLORANTS]

___ is a pigment consisting of a substratum of alumina hydrate on which the dye is absorbed or precipitated.

substratum of alumina hydrate

[COLORANTS]

FD and C lake is a pigment consisting of a ____ on which the dye is absorbed or precipitated.

● FD & C

● D & C

● External D & C

[COLORANTS]

Classification of Certified Colored Additives [3]

FD & C

[COLORANTS]

used in food, drugs, and cosmetics

D & C

[COLORANTS]

Approved for use in drugs, SOME in cosmetics, and SOME in medical devices.

External D & C

[COLORANTS]

This is restricted to EXTERNAL parts of the body, NOT INCLUDING the LIPS or any body surface covered by MUCOUS MEMBRANE.

● Capsules

● Compressed tablets

● Sugar-coated tablets

● Suspensions

[COLORANTS]

Drug products REQUIRING colorants [4]

● Ophthalmic products

● Parenteral products

● Ointments

● Suppositories

[COLORANTS]

Drug products that DO NOT CONTAIN color additives [4]

FD & C Yellow No. 5 (tartrazine)

[SAFETY CONCERNS OF SOME COLOR ADDITIVES]

• This can cause allergic reactions to patient allergy with ASPIRIN

• FDA requires the listing of this dye on the labels of food and ingested drugs containing the substance

FD & C Yellow No. 5 (tartrazine)

[SAFETY CONCERNS OF SOME COLOR ADDITIVES]

This can cause allergic reactions to patient allergy with ASPIRIN.

FD & C Yellow No. 5 (tartrazine)

[SAFETY CONCERNS OF SOME COLOR ADDITIVES]

FDA requires the listing of this dye on the labels of food and ingested drugs containing the substance

Aspirin

[SAFETY CONCERNS OF SOME COLOR ADDITIVES]

FD & C Yellow No. 5 (tartrazine) can cause allergic reactions to patient allergy with ___

Tartrazine

[SAFETY CONCERNS OF SOME COLOR ADDITIVES]

FD & C Yellow No. 5 is also known as ____

FD & C Yellow No. 5

[SAFETY CONCERNS OF SOME COLOR ADDITIVES]

Tartrazine is also known as ____

FD & C Red No. 4

[SAFETY CONCERNS OF SOME COLOR ADDITIVES]

This is now permitted only in EXTERNALLY applied DRUGS and COSMETICS because of unresolved safety questions.

FD & C Red No. 2 (Amaranth)

[SAFETY CONCERNS OF SOME COLOR ADDITIVES]

Certification of this colorant has been withdrawn since it can cause CANCER in RATS.

cancer in rats

[SAFETY CONCERNS OF SOME COLOR ADDITIVES]

Certification of FD & C Red No. 2 (Amaranth) has been withdrawn since it can cause ____

Amaranth

[SAFETY CONCERNS OF SOME COLOR ADDITIVES]

FD & C Red No. 2 is also known as ___

FD & C Red No. 2

[SAFETY CONCERNS OF SOME COLOR ADDITIVES]

Amaranth is also known as ___