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Haptoglobin
↓ with hemolysis
Lactate dehydrogenase
Indirect bilirubin
: ↑ with hemolysis
Direct Coombs test:
detects antibodies attached to RBCs, such as in erythroblastosis fetalis
Indirect Coombs test:
detects antibodies against foreign RBCs, which are present in autoimmune hemolytic anemia
Other serologic tests:
CMP: to evaluate renal and hepatic function
• Thyroid-stimulating hormone (TSH)
• Vitamin B12 level
• Folate level