rho chi exam 3

All of the following are true about diltiazem EXCEPT:

a) It is a benzothiazepine

b) It is an aryl-alkyl amine

c) It has low bioavailability due to ester group

d) It can be given PO and IV

b) It is an aryl-alkyl amine

True statements about the following drug include:

a. it has a 1,4-dihydropyridine parent nucleus

b. it is formulated as a HCL salt for IV Injection

c. it can be given PO
d. it has a basic nitrogen on the ester alkyl position 3

e. it acts on both cardiac and vascular tissues 

a,b,e

a,b,d

a,b,c,d

a,c,d

a,b,c,d

TRUE OR FALSE: The following drug has affinity to blood vessels only

• false 

SATA: Which of the following calcium channel blockers cannot be given IV?

a) Amlodipine

b) Diltiazem

c) Verapamil

d) Felodipine

a) Amlodipine

d) Felodipine

Which of the following agents cannot be given for the treatment of angina:

SELECT ALL THAT APPLY: True statements about this drug include...

a) The correct chemical name is glyceryl trinitrate

b) It is both moisture and heat sensitive due to ester group

c) It is very fast acting and very short acting

d) It is very hydrophilic

a) The correct chemical name is glyceryl trinitrate

b) It is both moisture and heat sensitive due to ester group

c) It is very fast acting and very short acting

TRUE OR FALSE: Isosorbide dinitrate has a longer kinetic half-life than isosorbide mononitrate.

• false 

Select the correct pairing of DRUG:MOA in the treatment of angina:

a) Calcium channel blockers: decreased afterload

b) Beta-blockers: increased contractility

c) Organic nitrates: decreased contractility

d0 Ranolazine: decreased preload

a) Calcium channel blockers: decreased afterload

(T/F): This drug should NOT be given to patients with asthma.

• true 

What is the class of this drug?

a) Beta-1 selective antagonist

b) Alpha-2 selective agonist

c) Non-selective alpha antagonist

d) Alpha-1a selective antagonist

d) Alpha-1a selective antagonist

What is true about this drug? (SATA)

a) This drug is atenolol

b) This drug vasodilates blood vessels

c) This drug decreases cardiac output

d) This drug is given by injection only

c) This drug decreases cardiac output

d) This drug is given by injection only

Which of the following are true about this drug? (SATA)

a) This is alpha-methyltyrosine

b) This is alpha methyl DOPA

c) This goes through active transport

d) This is used to treat BPH

a) This is alpha-methyltyrosine

c) This goes through active transport

All of these statements are true about this drug EXCEPT:

a) This can cause the release of nitric oxide from the epithelium

b) This is metabolized by N-acetyltransferase

c) This can induce hyperpolarization of blood vessel membranes

d) The metabolite of this drug is more lipophilic

c) This can induce hyperpolarization of blood vessel membranes

What of the following is NOT true about this drug?

a) This drug can potentially cause an allergic reaction

b) This drug is a competitive antagonist at the endothelin receptor

c) This drug is a competitive antagonist at the angiotensin II receptor

d) This drug is used in the treatment of pulmonary hypertension

c) This drug is a competitive antagonist at the angiotensin II receptor

What is true about the following drug? (SATA)

a) This drug prevents the conversion of angiotensin 1 to angiotensin 2

b) This drug's carboxylic acid binds to zinc on ACE

c) This drug's amine binds to zinc on ACE

d) This drug can taste like garlic

a) This drug prevents the conversion of angiotensin 1 to angiotensin 2

b) This drug's carboxylic acid binds to zinc on ACE

What is FALSE about candesartan? (SATA)

a) This drug is a polypeptide

b) This drug can be taken by mouth

c) This drug has a biphenyl and tetrazole

d) This drug blocks ACE

a) This drug is a polypeptide

d) This drug blocks ACE

Which of the following works in the proximal tubule?

Arrange the following thiazide diuretics most potent to least potent:

a) HCTZ, Polythiazide, Bendroflumethiazide

b) Polythiazide>Bendroflumethiazide>HCTZ

c) Bendroflumethiazide>HCTZ>Polythiazide

f) Polythiazide>HCTZ>Bendroflumethiazide

b) Polythiazide>Bendroflumethiazide>HCTZ

SATA True statements about this drug

a) It has a spiro two rings fused together at 1 atom

b) Is a K+ sparing diuretic and can cause Hyperkalemia

c) It works in the distal tubule

d) Competes with aldosterone at the receptor sites

a) It has a spiro two rings fused together at 1 atom

b) Is a K+ sparing diuretic and can cause Hyperkalemia

d) Competes with aldosterone at the receptor sites

T/F Ethacrynic acid can cause allergic reactions

• false

All of the following are correct about this drug EXCEPT:

a) Is a High ceiling diuretic trade name is Lasix

b) Can cause Hypokalemia

c) The carboxylic group will cause allergic reactions

d) Has a carboxylic group makes it conjugated to phase 2 more easily

c) The carboxylic group will cause allergic reactions

SATA: Select all true statements

a) Statins will inhibit the conversion to Mevalonic Acid

b) Simvastatin is a prodrug

c) Remnant chylomicrons has cholesterol ester, Cholesterol, and TG outside

d0 Nicotinic acid is also a peripheral vasoconstrictor

a) Statins will inhibit the conversion to Mevalonic Acid

b) Simvastatin is a prodrug

SATA: Select true statements about this drug

a) Is metabolize by esterase hydrolysis

b) Is a Aryloxyisobutyric acid derivative

c) It lowers LDL levels

d) Trade name is Mevacor

a) Is metabolize by esterase hydrolysis

b) Is a Aryloxyisobutyric acid derivative

SATA: Select true statements about Cholestyramine

a) Trade name is Questran

b) It has a quaternary ammonium in its structure and is a polymer of styrene

c) Causes severe diarrhea

d) Is a bile acid sequestrant

a) Trade name is Questran

b) It has a quaternary ammonium in its structure and is a polymer of styrene

d) Is a bile acid sequestrant