Practice Questions: other HIV agents

cobicistat is an analog of which drug?

a. ritonavir

b. stavudine

c. indinavir

d. dolutegravir

a

which of the following is FALSE about cobicistat?

a. the back bone OH group of ritonavir has been removed

b. the structural changes made to ritonavir to make cobicistat keeps both the anti-HIV effects and the inhibitory effects

c. it works via inhibiting CYP3A4, intestinal transport proteins and liver enzymes

d. it can lead to SCr increases but this can be reversed if the medication is d/c

b

which of the following is inhibited by cobicistat?

a. CYP3A4 enzymes

b. intestinal transport enzymes

c. liver enzymes

d. all of the above

d

TDF + cobicistat can only be taken in pts if…

a. they are at least 3 years old

b. they weigh > 88 lbs

c. their CrCl is > 70

d. all of the above

c

which of the following is true regarding atazanavir + cobicistat?

select all that apply

a. the brand name is Evotaz

b. the pt must be at least three years old to take it

c. the brand name is Epzicom

d. the patient must weigh more than 77 lbs to take it

a and d

which of the following is false about darunavir + cobicistat?

a. the patient must weigh at least 88 lbs to take it

b. the patient must be at least 3 years old to take it

c. the patient must have a CrCl > 80 to take it

d. the brand name is Prezcobix

c

which of the following drugs and MOA’s are not correctly matched?

a. enfuvirtide; fusion inhibitor

b. cobicistat; entry inhibitor

c. maraviroc; entry inhibitor

d. fostemsavir; entry inhibitor

b

which of the following drugs works by binding to gp41 to prevent the creation of an entry pore for the capsid of the virus so it can’t infiltrate host cells?

a. fostemsavir

b. maraviroc

c. ibalizumab

d. enfuvirtide

d

which of the following is FALSE about fostemsavir?

a. it works via binding to gp41 to block HIV from making an entry pore for the capsid so the virus cannot enter the host cells

b. the brand name is Rukobia

c. it works via binding to gp120 to block HIV from entering the immune cells

d. its unique MOA confers relative confidence that it will work on strains of HIV that are resistant to most other anti-retroviral medications

a

which of the following is TRUE about Ibalizumab?

a. it alters the structure of CCR5

b. it is a post-attachment inhibitor

c. it is an entry inhibitor

d. it is a fusion inhibitor

b

which of the following is FALSE about Ibalizumab?

a. the brand name is Trogarzo

b. it should be given via IV infusion for 15-30 mins every 2 weeks

c. the brand name is Rukobia

d. it is indicated only for experienced patients

c

which of the following drugs works via altering the structure of CCR5 receptors so that the HIV virus will not bind to the immune cells?

a. cobicistat

b. fostemsavir

c. enfuvirtide

d. maraviroc

d

which of the following is FALSE regarding maraviroc?

a. when taken with CYP3A4 inducers, the dose should be 300 mg BID

b. patients must have a Trofile test done to determine if they are eligible to take it

c. it can lead to upper respiratory infections, orthostatic hypertension, and hepatotoxicity

d. when taken with CYP3A4 inhibitors, the dose should be 150 mg BID

a

which of the following dosing regimens is FALSE?

a. cobicistat 150 mg + ketoconazole

b. cobicistat 150 mg + phenytoin

c. cobicistat 300 mg + nevirapine

d. cobicistat 600 mg + efavirenz

b