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Is any exercise 100% aerobic or anaerobic?
No, all exercise uses both systems
What are the two main ways anaerobic effort is estimated?
Lactate threshold and EPOC
What is lactate threshold (LT)?
Point where blood lactate accumulation increases rapidly
What is the physiological cause of lactate threshold?
Lactate production rate exceeds lactate clearance rate
What systems interact at lactate threshold?
Aerobic and anaerobic systems
How is lactate threshold usually expressed?
% of VO2max
Why is lactate threshold a good endurance indicator?
Higher LT allows sustained higher intensities
If two athletes have the same VO₂max, who performs better?
The one with the higher lactate threshold
What causes oxygen deficit during early exercise?
ATP demand exceeds oxygen consumption
Why does oxygen consumption remain elevated post-exercise?
Excess postexercise oxygen consumption (EPOC)
What is the primary purpose of EPOC?
Restore the body to pre-exercise state
What does EPOC help replenish?
ATP and PCr stores
What happens to lactate during EPOC?
Converted to glycogen or oxidized
What other processes occur during EPOC?
Replenish hemo/myoglobin O2, clear CO2
What hormones are elevated during EPOC?
Epinephrine and norepinephrine
What are two common definitions of fatigue?
Performance decrement with effort OR inability to maintain required power
What distinguishes fatigue from muscle damage?
Fatigue is reversible with rest
What are the four major causes of fatigue?
↓ energy delivery, ↑ metabolic by-products, contractile failure, altered neural control
Why does PCr depletion cause fatigue?
Limits ability to rapidly resynthesize ATP
Which depletes faster: ATP or PCr?
PCr
How does pacing affect PCr depletion?
Slows depletion and delays fatigue
Is glycogen depletion linked to fatigue?
Yes, strongly correlated
Is fatigue related to rate or total glycogen depletion?
Total depletion, not rate
When does glycogen deplete fastest?
High-intensity exercise and early in exercise
What is the fiber recruitment order related to glycogen depletion?
Type I → Type IIa → Type IIx
What is the role of liver glycogen during prolonged exercise?
Maintains blood glucose
What causes fatigue during long exercise?
Muscle glycogen depletion + hypoglycemia
What are key fatigue-related metabolic by-products?
Pi, lactate, H+
Why is H⁺ accumulation problematic?
Causes acidosis and ↓ muscle pH
How do buffers help during exercise?
Limit pH drop (7.1 → 6.5)
What happens if pH <6.9?
Inhibits glycolytic enzymes and ATP synthesis
What happens at pH ~6.4?
Prevents further glycogen breakdown
How does heat affect metabolism?
Increases carbohydrate use and glycogen depletion
At what temperature is time to exhaustion longest?
~11 °C
At what temperature is time to exhaustion shortest?
~31 °C
How does muscle precooling affect fatigue?
Prolongs exercise time
Where can neural fatigue occur?
Neuromuscular junction or CNS
What are possible NMJ causes of fatigue?
↓ ACh release, altered membrane potential, ↓ Ca2+ release from SR
How does the CNS contribute to fatigue?
Conscious or subconscious reduction in motor drive
Why do elite athletes fatigue differently?
Better pacing and tolerance of discomfort
Summarize fatigue in one sentence.
Fatigue is a reversible decline in performance caused by interacting metabolic, neural, and energetic factors