Microtubule associated proteins (MAPS) + cilia

MTOC

microtubule organizing center, in animal cells it is the centrosome

centrosome

nucleates microtubules, sphere that containes the centrioles and the gamma-tubulin

gamma(y) tubunin ring complex (y-TURC)

nucleates microtubules with the minus(a-tubulin) side binds directly to y-tubulin ring and grows outward (+)

kinesin

(ATPase) molecular motors that carry cargo towards axon (+ end)

cytoplasmic dynein

(ATPase) molecular motors that carry cargo toward cell body (-end)

basal body

base of cilia, short cylinder of triplet microtubules

9+2

motile cilia, has two inner microtubules, nine doublets, has ciliary dynein, radial spokes, nexin

9+0

non motile cilia/flagella, has no inner microtubules, has nine doublets

axoneme

cilia have microtubule based protrusion called the

ciliary dynein

link to A doublet, allow contraction on one side and relaxation on one side with power stroke to allow it to squiggle

Radial spokes

anchor outer doublets to hte middle

Nexin

links to outer doublets

Kartagener’s syndrome

cilia is missing dynein

IFT trains

molecular motors that transport materials to the tip and return to the base

Primary cilium

(9+0) is non-motile and short, acts as a sensor, lacks ciliary dynein and

GFAP

expressed in astrocytes