M121 Lec 9 MHC

MHC

Major Histocompatibility complex

Antibody binds ______ to the antigen

directly

MHC molecules present antigen and they presented to _______

T cells

Teclls are compromised of _______ (helper) and _____ (killer).

CD4+, CD8+

MHC I presents antigen to the ______ cells and the MHC II presents antigen to the _____ cells.

CD8+, CD4+

The human MHC is also called _____, just to confuse things. It's on chromosome ____, it's about ______ kb and it's around _____ genes.

HLA, 6, 4,000, 100

MHC in humans have genes coding for three molecules called ____, ____, and _____.

Each of them has an _____ and a _____chain.

DP, DQ, DR, alpha, beta

MHC I have _______, on the surface of cells, transmembrane. They are on all _______ cells.

glycoproteins

Antigens are _____, which are just very short stretches of protein, so around _____ amino acids. MHC I present them from ______ sources. The present to _____ T cells. It __is/ is not__ infected.

peptides, 10-12, endogenous, CD8+, is

An good example of endogenous source is _____, the peptides from the viral protein, would get presented on an MHC class ___ molecule.

virus, 1

MHC II molecules have ______ that are transmembrane they present _____ antigen, also peptide. It __is/ is not__ infected.

glycoproteins, exogenous, is not