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The reduced stimulation of glycolysis following an endurance training leads to a(n) _____.
lower oxygen deficit
The high levels of _____ _____ across the muscle membrane during resistance training appear to be a primary signal that promotes contractile protein synthesis.
mechanical stretch
Identify a biochemical adaptation by which endurance training increases the capacity to transport free fatty acids (FFA) into the mitochondria.
by dramatically increasing fatty acid translocase
Increased capillary density
enhances the delivery of free fatty acids to the muscle
Expanded transport ability
moves free fatty acids across the sarcolemma and from the cytoplasm into the mitochondria
Increase in mitochondria numbers
converts free fatty acids to acetyl-CoA units for metabolism in the Krebs cycle
Identify the training-induced biochemical changes involved in maintaining the pH level of blood.
1. decreased lactate and H+ formation
2. Decreased pyruvate production
The group III and group IV nerve fibers provide a _____ _____ mechanism that contributes to the regulation of the cardiovascular and respiratory responses during exercise.
peripheral feedback
Rank the biochemical adaptations following endurance training according to the order in which they occur.
1. increase in both the subpopulations of mitochondria-subsarcolemmal and intermyofibrillar in muscle fibers
2. elevation of the enzyme involved in fatty-acid beta-oxidation
3. increased rate at which acetyl-CoA molecules are formed from free fatty acids for entry to the Krebs cycle
4. High rate of beta oxidation and increased levels of citrate in the muscle
5. inhibition of rate-limiting enzyme in glycolysis
6. decrease in carbohydrate metabolism and increase in lipid oxidation
Identify the key change that occurs due to endurance training, which results in the decrease of sympathetic nervous system activity, during submaximal exercise.
increased in mitochondrial number
Hyperplasia
it refers to an increase in the total number of muscle fibers within a specific muscle.
Hypertrophy
it refers to an increase in muscle fiber cross-sectional area.
The smaller group of mitochondrial subpopulation that rests immediately beneath the sarcolemma is called subsarcolemmal mitochondria, and the larger group that is dispersed around the contractile proteins is called _____ mitochondria.
intermyofibrillar
Identify the genetic factors that contribute to the high VO2 max values possessed by elite male and female endurance athletes.
1. a high percentage of slow muscle fibers
2. a large cardiovascular capacity
Identify a true statement about afterload.
afterload is reduced in trained muscles.
A single bout of resistance exercise can elevate the rate of muscle protein synthesis for up to _____.
24 hours
Preload
end diastolic volume
Afterload
total peripheral resistance
Identify neural adaptations that are caused by resistance training.
1. improved ability to recruit motor units
2. alterations in motor firing rates
Rank the processes that meet the need for adenosine triphosphate during exercise according to the order in which they occur.
1. phosphocreatine response
2. glycolysis
3. mitochondrial oxidative phosphorylation
The corollary of the _____ principle is the principle of reversibility.
overload
Endurance training results in a decrease in _____ during prolonged submaximal exercise.
the utilization of plasma glucose
Rank the biochemical responses to endurance training according to the order in which they appear.
1. activation of free radicals
2. increased mitogen activated kinase
3. activation of PGC-1a
4. Mitochondrial biogenesis
The _____ principle refers to the fact that an organ system or tissue must be exercised at a level beyond which it is accustomed in order to achieve a training adaptation.
overload
Endurance training of muscles results in a(n) _____.
increase in mitochondria number
Unlike muscular strength, muscular endurance refers to the _____.
ability to make repeated contractions against a submaximal load
In contrast to detraining in endurance training, detraining in resistance training _____.
occurs at a slower rate
Rank the activities involved in resistance exercise-induced protein synthesis according to the order in which they occur.
1. muscle mechanical stretch
2. synthesis of insulin-like growth factor 1
3. activation of protein kinase B molecule
4. activation of mTOR molecule
5. increase in mRNA translation
The increased capacity of the muscle to extract oxygen following training is primarily due to a(n) _____.
increase in capillary density
Identify a true statement about 5'adenosine monophosphate activated protein kinase.
it stimulates glucose uptake and fatty acid oxidation.
the VO2 max has been found to be less than 20 ml/kg/min in _____.
patients with severe pulmonary disease
Rank the big picture process of exercise-induced training adaptation according to the order of which it occurs.
1. muscle contraction
2. increase in primary and secondary messengers
3. initiation of cascade of coordinated signaling events
4. increased expression of specific genes
5. synthesis of specific proteins
High-intensity interval training
AMPK and PGC
endurance exercise
P38, CaMK, Calclineurlin, AMPK
resistance training
IGF-1/mTOR and NFkB
Identify a true statement about maximal oxygen uptake.
it involved marge muscle groups
an increase in the end diastolic volume stretched the left ventricular wall, causing cardiac muscle to contract more forcefully via the _____.
Frank-Starling mechanism
Identify the type of individual who experiences improvements in Vo2 max with relatively low training intensities.
those with low VO2 max prior to training
Identify a true statement about endurance training-induced changes in myosin isoforms.
it results in a fast-to-slow shift in myosin isoforms
T/F: Prolonged endurance training increases the size of the left ventricle with little change in ventricular wall thickness.
true
The level of _____ in the muscle cytosol is determined by the mode, intensity, and volume of exercise.
free calcium
Identify a primary signaling event that occurs due to repeated muscle contractions.
release of calcium
T/F: Even a few weeks of exercise training can result in large increases in maximal heart rate.
False; exercise training does not increase maximal heart rate and, in fact, months of training result in a small decrease in maximal heart rate.
Endurance training protects muscle damage by increasing the levels of _____.
endogenous antioxidants
T/F: The magnitude of the exercise-induced increase in mitochondria in muscle is dependent upon both the exercise intensity and duration.
True
Identify a primary signal for muscle adaptation.
muscle stretch
Strength training-induced shifts in muscle fibers are less prominent than endurance training-induced transformations because all of the change in fiber type is a movement from _____ fibers.
type llx to type lla
This signaling molecule is activated during high-intensity interval training due to changes in muscle fiber phosphate levels.
AMPK
Identify a primary signal molecule involved in muscle adaptation as a response to endurance training.
decreases in muscle phosphatase
Prolonged endurance training can typically increase muscle mitochondrial protein by _____ within the first six weeks of training.
50% to 100%
The fast-to-slow shift in myosin isoforms as a result of endurance training to physiologically important because it _____.
increases mechanical efficiency
_____ is the measure of the maximal capacity of the body to transport and use oxygen during dynamic exercise using large muscle groups.
Maximal oxygen uptake
_____ trigger a signaling cascade that leads to mitochondrial biogenesis.
repeated muscle contractions
During endurance training, a(n) _____ contributes to augmented venous return and increased end diastolic volume
increase in plasma volume
All training-induced increases in maximum cardiac output must come from a(n) _____.
increase in stroke volume