Citric Acid Cycle Flashcards

Vocabulary flashcards for the Citric Acid Cycle, covering key steps and enzymes.

Acetyl-CoA

A two-carbon compound that is the starting point for the TCA cycle, obtained from the breakdown of carbohydrates, fats, and proteins.

Citrate Synthetase

The enzyme that catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate in the first step of the citric acid cycle.

Aconitase

The enzyme that catalyzes the isomerization of citrate to isocitrate, involving the intermediate cis-aconitate.

Isocitrate Dehydrogenase

The enzyme that converts isocitrate to alpha-ketoglutarate, producing CO2 and NADH2.

Alpha-ketoglutarate Dehydrogenase Complex

A multi-enzyme complex that converts alpha-ketoglutarate to succinyl-CoA.

Succinic Thiokinase

The enzyme that converts succinyl-CoA to succinate, converting GDP to GTP in the process.

Succinate Dehydrogenase

The enzyme that converts succinate to fumaric acid, converting FAD to FADH2.

Fumarate Hydratase (Fumarase)

The enzyme that catalyzes the hydration of fumaric acid to form malate.

Malate Dehydrogenase

The enzyme that dehydrogenates malate to produce oxaloacetate, converting NAD to NADH2.

Oxaloacetate

A four-carbon compound that reacts with acetyl-CoA to form citrate and restart the citric acid cycle.