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Where does it happen
mitochondrial matrix
1st step is…
removal of carboxyl group from pyruvate, turning it into an acetyl group (C = O w/ CH3)

2nd step is…
acetyl group turns into acetyl-coA

Net gain (per 1 glucose/2 pyruvate)
2 NADH
2 CO2
2 acetyl-coA
net and total gain is the same
What is pyruvate dehydrogenase complex?
3 enzymes that turn pyruvate into acetyl-coA
1st enzyme releases CO2
2nd enzyme puts in Co-A
3rd enzyme reduces NAD+