Cellular Autonomic NS

M2 receptor

Location

• Heart, nerves, smooth muscle

Responses

• Decrease HR, decrease contractility

Mechanism

• Gi - Decrease cAMP, activates K+ channels

M3 receptor

Location

• Smooth muscle

Responses

• Contraction

Mechanism

• Gq: PLC, IP3, DAG

Nicotonic receptor

Location

• Neuromuscular junction, postganglionic body, CNS

Responses

• ESPs, action potentials

Mechanism

• Ion channel permeability to Na+ and K+ → depolarization

Alpha-1 receptor

Location

• Smooth muscle (vascular, bladder, GI sphincters)

Responses

• Contraction

Mechanism

• Gq - PLC, IP3, DAG

Alpha-2 receptor

Location

• Presynaptic nerve terminals, vascular smooth muscle

Responses

• Decrease release of NE

Mechanism

• Gi - Decrease cAMP

Beta-1 receptor

Location

• Heart, renal cells

Responses

• Increase heart rate, increase renin (kidney)

Mechanism

• Gs - Increase cAMP

Beta-2 receptor

Location

• Smooth muscle (vascular, bladder, GI sphincters)

Responses

• Relaxation

Mechanism

• Gs - Increase cAMP

Dilate, Beta-2, constricts, M

The bronchioles __ (dilate/constrict) at the __ _ receptor in the sympathetic NS

The bronchioles __ (dilate/constrict) at the __ receptor in the parasympathetic NS

M1, M2, M3, Alpha1, Alpha2, Beta1, Beta2, Constrict, constrict, relax

Q -

I -

Q -

Q -

I -

S -

S-

Actions from G receptors on muscle (constrict/relax)

Q - __

I - __

S - __

Sympathetic

Some organs are only innervated by the __ (sympathetic vs parasympathetic) nervous system

(i.e. vasculature, sweat glands, kidney, adipose tissue)

nAChR

__ are ligand-gated ion channels to the neuromuscular junction, permeable to Na+ and K+

G protein-coupled receptors (GPCRs)

Have subunits that stimulate enzymes to produce second messengers

cAMP, IP3, DAG

Adenylyl cyclase (AC) → __

Whereas Phospholipase C (PLC) → __ & __

q, contraction

G_ CRs stimulate Ca2+ release and activate protein kinase C (PKC)

• Phosphorylates targets → Ca2+ binding proteins → Ca2+ release from E. reticulum

• Stimulate smooth muscle __ (contraction/relaxation)

M1, M3, Alpha1

Gq receptor actors

• Cholinergic = __ receptors (2)

• Adrenergic = __ receptors

s, relaxation, contraction

G__ CRs stimulate adenylyl cyclase, cAMP, and activate protein kinase A (PKA)

Stimulate smooth muscle __ (contraction/relaxation) and cardiac muscle __ (contraction/relaxation)

Beta 1

Gs receptor actors

• Adrenergic = __ receptors

i, heart

G_ CRs inhibit adenylyl cyclase, decrease cAMP, inactivate protein kinase A (PKA)

Decrease __ rate

M2

Gi receptor actors

• Cholinergic = __ receptors on cardiac pacemakers

M2, Beta-gamma, K, decrease

The __ metabotropic Rs also initiate __ subunit to detache and activate nearby __ + channels

• Increase in permeability to this ion may lead to hyperpolarization

• __ (increase/decrease) in heart rate

pre

receptors on the __-synaptic neuron initiate negative feedback

Post, adrenal medulla

__-ganglionic sympathetic nerves release NE

The __ __ releases epinephrine to blood (as a neurohormone)

Contraction, contraction

Parasympathetic control of eye

• __ of iris sphincter (pupil constriction)

• __ of the ciliary muscle (near vision)

contraction, relaxation

Sympathetic control of eye

• __ of radial muscle (pupil dilation)

• __ of the ciliary muscle (far vision)

Constriction, increase

Parasympathetic control of lungs

• broncho__ (relaxed breathing)

• __ in release of secretions

Dilation, decrease

Sympathetic control of lungs

• broncho__ (relaxed breathing)

• __ in release of secretions

Voiding, relaxation, contraction

Parasympathetic control of bladder

• __ of urine

• Sphincter __

• Detrusor __

Retention, contraction, relaxation

Sympathetic control of bladder

• __ of urine

• Sphincter __

• Detrusor muscle __

Contraction, constriction, radial, contraction, accommodation

Muscarinic agonist to eye results in…

• __ of iris circular (sphincter) with pupil __

• no effect on iris __

• __ of ciliary circular with pupil __

Relaxation, dilation, radial, relaxation, paralysis

Muscarinic antagonist to eye results in…

• __ of iris circular (sphincter) with pupil __

• no effect on iris __

• __ of ciliary circular with pupil __ (cycloplegia)+ pupil dilation

Contraction, dilation

Alpha-1 agonist to eye results in…

• __ of the iris radial and pupil __

• No effects noted to iris circular (sphincter) or ciliary circular