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connective tissue is _____ meaning it is related to or being the tissues that surround a joint
periarticular
define periarticular
related to or being the tissues that surround a joint
what do periarticular (connective) tissues do in response to functional demands and a changing loading environment
change structure
2 common elements in periarticular tissue
cells and extracellular matrix
3 connective tissues
bone, cartilage (hyaline and fibrocartilage), and dense (capsule, ligament, tendon)
2 elements of extracellular matrix
interfibrillar (ground substance) and fibrillar (fibrous)
cells in connective tissue synthesize what
extracellular matrix
what are the most basic cells in the connective tissue
fibroblasts
fibroblasts (most basic cells in connective tissue) may ____ into specialized cells
differentiate
interfibrillar part of the EC in connective tissue is ___ ___
ground substance
what is the interfibrillar part of the EC made of
water and proteins
2 parts of the extracellular matrix in connective tissue
intrafibrillar and fibrillar
what is in the fibrillar part of the extracellular matrix of connective tissue
collagen (type 1, 2, 3) and elastin
define type I collagen
most common, thick, tensile strength
define type II collagen
thinner, found in cartilage where compressive forces are common
define type III collagen
found in skin, capsule, muscle/tendon sheaths where tensile stresses are common
type 1, 2, 3 collagen help with what stresses, respectively
tensile, compressive, tensile
elastin (in ____ part of EC in connective tissue) resists ____
fibrillar, tension
4 types of cells found in connective tissue
fibroblasts, tenoblasts, chondroblasts, osteoblasts
fibroblasts found in ____
tenoblasts in ____
chondroblasts in _____
osteoblasts in _____
ligaments, tendons, cartilage, bone
dense connective tissue is ___ and ___
tendons and ligaments
fibrous tissue has few _____, moderate _____ and ____, and lots of tightly packed ____
fibroblasts, elastin, PG, collagen
dense connective tissue (tendons and ligaments) is _______
fibrous
ligaments connect ___ to ____
bone to bone
3 roles of liagments
allow normal joint motion (guide arthrokinematics), provide stability (prevent abnormal motion) and have a role in proprioception (nerve fibers)
tendons connect
bone to muscle
role of tendons
transmit muscle forces to move bones
ligaments resist _____ only
tension
ligaments do no resist _____
compression
ligaments are ___ not ___
ropes, bars
since _____ in ligaments runs in many directions, they can resist forces in more than one direction
collagen
ligaments guide motion:
ankle - ___
PCL - ___
ACL - ___
guides linear action of muscles into rotation
femoral rollback
screw home
ligaments 3 main features
resist tension only
guide motion
provide stability
during dynamic movement, ____ are the first line of defense
muscles
enthesis = ______
attachment
tendons and ligaments attachment is either
____ or ____
direct, indirect
direct attachment in tendons and ligaments is via
fibrocartilage
indirect attachment in tendons and ligaments is via
fibrous attachments
direct attachment via fibrocartilage in tendons and ligaments is __ or __ zones of increasing _____ with continuous ____ fibers
3, 4, calcification, collagen
the indirect attachment in tendons and ligaments is when ___ fibers blend into the ____ and the ____ is linked to cortical ____ via ____ fibers
collagen, periosteum, periosteum, bone, Sharpeys
bone to tendon junction has
4 zones of increasing calcification
tendon to bone and tendon to muscle connections are both ____
direct
tendons and ligaments contain mostly type ___ collagen, which has the most ____ strength of all types
I, tensile
tendons have a more ____ alignment of collagen than ligaments; this is a reflection of the ____ placed on them
parallel, stresses
ligaments vascular supply inside is ____
endoligamentous
ligaments vascular supply outside the tissue is ____
epiligamentous
vascular supply in ligaments is through diffusion of nutrients to cells from ____ _____
synovial fluid
normal turnover of collagen - half in ___-___ days
300, 500
ACL and PCL theories (4)
no initiation of inflammatory response
inhibition of inflammatory response
lack of nutrition
clot washed away by synovial fluid
special new surgery for ACL
BEAR (bridge enhanced ACL repair)
if injury is sustained in one component, ___ is ___ in other components
loading, increased