Immunity phys

Recombination of V, D, and J gene segments:

requires recombinase enzymes

Monoclonal antibodies are produced by cells derived from a fusion between

Monoclonal antibodies are produced by cells derived from a fusion between:

B cell in a spleen (not right), B cell and a myeloma cell (right)

When a T cell receptor binds its antigen, which of the following is responsible for signal transduction via ITAMs?

CD3

Which immunoglobulin class is the first to be expressed on the surface of maturing B cells?

IgmM

An immunoglobulin Fab fragment:

binding antigens

Under which of the following conditions does a B-cell have an opportunity to edit (change) its fully functional epitope-specific receptor? A B-cell can undergo receptor editing when:

the receptor is highly specific for a tumor epitope (not right), igm

If a developing B-cell expresses ONLY the IgM isotype version of a (functional) epitope-specific receptor and that B-cell forms high affinity bonds with several identical self-epitopes on the surface of any cell in the bone marrow (i.e., this is a multivalent epitope binding event), which of the following will occur (do NOT consider receptor editing as a possibility)? The B-cell will:

B7 on an antigen presenting cell binds to which of these T cell ligands?

Which of the following is NOT a T cell receptor chain?

gamma (not right), Y (not right), E (right)

Which of these is/are required for full activation of a helper T lymphocyte?

I and II (CD28 binding to B7 )

Terminal deoxynucleotidyl transferase is required forThe T cell receptor (TCR) is:

terminatinating (not right), splicing gene segments together during somatic recombination (not right), ecombination of V, D, and J gene segments (not right)

The T cell receptor (TCR) is:

hetrodimer

B7 on an antigen presenting cell binds to which of these T cell ligands

CD28

Which of the following is TRUE about an immature T cell?

vs. pro T cell

A recombined μ heavy chain and surrogate light chains (right)/ It is double negative and expresses a surrogate TCR. (not right), t is double positive and expresses a surrogate TCR (not right)

It is double negative and does NOT express a TCR (right)

The initiation of the somatic recombination events is controlled by which one of the following?

RAG products (right)

When a B-cell is maturing, it can check each attempt at heavy chain production by associating that heavy chain with which one of the following at the surface of the developing B-cell?

light chain

An immunoglobulin Fab fragment:

binds antigens

Even if ALL of the possible somatic recombinations occur using every one of the available receptor gene fragments, the resulting number of different receptor specificities is far less than the actual number of specificities most immunologists believe are produced. The additional specificities are likely the result of which one of the following events?

A unique type of transfer RNA (tRNA) is used to form the bonds between the amino acids as they are assembled into the complete chains (Not right), Isotype switching induced by cytokines being released by T-regulatory cells. (not right)

c.

Random insertion of one or more nucleotides between gene fragments as they are being ligated.(right)

Which of the following is TRUE about a pro-T cell?

It is double negative and expresses a surrogate TCR.

What is the approximate number of D gene segments in the immunoglobulin light chain gene locus?

1 (not right), 0 (right)

When a T cell receptor binds its antigen, which of the following is responsible for signal transduction via ITAMs?

.

the TCR β chain or alpha (not right), CD3 (right)

Complementarity determining regions:

are important for antigen recognition. (right)

When a T cell receptor binds its antigen, which of the following is responsible for signal transduction via ITAMs?

CD3 (right)

A pre-B cell expresses which of the following on its plasma membrane?

A recombined μ heavy chain and surrogate light chains (right)

Which of the following molecules induces survival and proliferation in activated T cells?

IL-2 (right)

An immature B cell expresses which of the following on its the plasma membrane?

A recombined μ heavy chain and a surrogate light chain (not right),

A surrogate μ heavy chain and a recombined light chain (not right)

A surrogate μ heavy chain and a surrogate light chain (not right)

.

A recombined μ heavy chain and a recombined light chain (right)

Which of the following is TRUE about an immature T cell?

It is double negative and expresses a surrogate TCR (not right),

It is double negative and expresses a TCR (not right)

It is double positive and expresses a surrogate TCR (not right)

It is double positive and expresses a TCR. (right)

If a developing B-cell expresses ONLY the IgM isotype version of a (functional) epitope-specific receptor and that B-cell forms high affinity bonds with several identical self-epitopes on the surface of any cell in the bone marrow (i.e., this is a multivalent epitope binding event), which of the following will occur (do NOT consider receptor editing as a possibility)? The B-cell will:

undergo apotosis (right)

When a B-cell is maturing, it can check each attempt at heavy chain production by associating that heavy chain with which one of the following at the surface of the developing B-cell?

surrogate light chain