Orgo Lab 2: Nitration

What is a EAS reaction?

electrophilic aromatic substitution

What are the 3 steps of a nitration?

1. Generation of the electrophile

2. Electrophilic attack on aromatic system

3. Re-aromatization

What is the solvent of a nitration reaction?

H2SO4

EAS reactions are generally what order reactions?

Second order

Rate law for EAS reaction

K[arene][electrophile]

What is the nitro functional group?

NO2-

Which has higher mw, mp, bp, methyl benzoate or methyl nitrobenzoate?

Methyl m-nitrobenozoate

The electrophile in the reaction is there nitronium ion which is generated _____ or in the reaction mixture

In situ

Overall reaction for nitration

HO-NO2 + H-HSO4 —> NO2 + HSO4 + H2O

True or False: Higher the temperature, greater will be the amounts of dinitration products formed.

True

An acid spill is neutralized using

Solid sodium carbonate or bicarbonate

Concentrate nitric acid and sulfuric acid are both

Strong oxidizers and high corrosive

What analysis will be used in this lab?

TLC analysis

For the TLC Solent it will be a _ Hexane to _ EA

4:1

Which will travel further on the TLC plate, Methyl Benzoate or m-nitromethyl benzoate?

Methyl benzoate