Fatty Acid Metabolism Need To Know

Fatty Acid Oxidation Catabolism (breaks)

Fatty acids—to acetyl coA (which can feed into CAC/Krebs)

number of rounds: (Carbons/2)-1

# of acetyl coA: (carbons/2)

number of rounds=number of FADH2 and NADH (produced)

For unsaturated fats 1 double bond=1- FADH2

*Happens in the mitochondrial matrix

Small amnt of ATP needed to start but can ultimitatly lead to more

Can create 106 ATP

Fatty Acid Synthesis Activation

Acetyl coA first binds to ACP then transfers to the active site then malonyl binds to the ACP

Fatty Acid Synthesis Anabolism (builds)

Acetyl coA—Palmitate (fatty acid)

Reverse of oxidation

NADPH—NADP^+

*Happens in the cytosol

Needs a lot of ATP to start

Creates palmitate from acetyl coA ( which can undergo further modifications in the smooth ER

Ketogenesis

Creating ketone bodies from acetyl coA

1: Acetoacetate

and then

2: Acetone

3: N-Hydroxybutyrate