cancer and transplantation

week 11

Which of the following immune cells is primarily responsible for mediating acute rejection in transplantation?
A. CD8 T cells
B. B cells
C. Neutrophils
D. Natural Killer (NK) cells

CD8 T cells

What is the role of immunosuppressants in transplantation?
A. To enhance the immune response
B. To stimulate T cells
C. To prevent the immune system from attacking the graft
D. To reduce cancer cell proliferation

To prevent the immune system from attacking the graft

____ _____ and _____ were demonstrated in Peter Medawar’s experiments, which were crucial for understanding transplant immunity.

Immune memory tolerance

____ _____ involves a more complex interaction between donor and recipient _____- _______.

Chronic rejection antigen-presenting cells

What role do T cells and NK cells play in cancer immunology?

They help detect and eliminate tumor cells through immune surveillance.

What is the primary therapeutic goal in transplantation immunology?

To suppress the immune system to prevent graft rejection.

What was a key historical breakthrough in reducing transplant rejection?

The discovery of MHC molecules and their role in immune rejection.

How does the immune system behave in cancer immunology compared to transplantation immunology?

In cancer immunology, the immune system is stimulated to attack tumors, while in transplantation, it is suppressed to prevent rejection.

What is cancer immunoediting?

The process by which tumors evolve to escape immune detection.

Early transplantations were often rejected due to a lack of understanding of ____ _____

immune rejection.

The concept of ___ _____ was crucial for reducing transplant rejection rates

MHC matching

Immunosurveillance theory suggests that the immune system detects and eliminates ___ ____ ____

early tumour cells.

In transplantation, immunosuppressants are used to prevent ____ ______ by targeting MHC-medicated responses

graft rejection

____ ______ escribes how tumors evolve to evade immune detection over time.

Cancer immunoediting

What role do T cells and NK cells play in cancer immunology?

They help detect and eliminate tumour cells through immune surveillance.

What is the primary therapeutic goal in transplantation immunology?

To suppress the immune system to prevent graft rejection.

What was a key historical breakthrough in reducing transplant rejection?

The discovery of MHC molecules and their role in immune rejection.

How does the immune system behave in cancer immunology compared to transplantation immunology?

In cancer immunology, the immune system is stimulated to attack tumors, while in transplantation, it is suppressed to prevent rejection.

What is cancer immunoediting?

The process by which tumors evolve to escape immune detection.