cancer and transplantation

week 11

Which immune cells are primarily responsible for acute transplant rejection?

CD8 T cells

What is the main purpose of immunosuppressants in transplantation?

To prevent the immune system from attacking the transplanted organ

What key findings did Peter Medawar’s experiments reveal about transplant immunity?

Tolerance, rejection, and specificity

What was a major scientific discovery that reduced transplant rejection?

The identification of MHC molecules and their role in immune recognition

What is tissue matching, and why is it important in transplantation?

It ensures donor-recipient compatibility, reducing the risk of rejection

What is cancer immunoediting?

The process by which tumors adapt to evade immune detection

How do T cells and NK cells contribute to cancer immunity?

They detect and destroy tumor cells through immune surveillance

How does the immune response differ between cancer and transplantation contexts?

It’s stimulated in cancer to fight tumors, but suppressed in transplantation to prevent rejection