Drugs for ADHD and Narcolepsy

What drugs interfere with storage and reuptake of catecholamine?

ADHD drugs

What ADHD drug is contraindicated for use with CVD, has adverse drug interactions with MAOIs, serotonergic agents; a box warning for high abuse potential with serious cardiovascular adverse reactions; and a duration of action that increases with dose?

Amphetamine/dextroamphetamine mixed salts

What ADHD drug is contraindicated with motor ticks/Tourette's syndrome, anxiety; has adverse drug reactions with MAOIs; has a box warning for caution in drug or alcohol abuse that requires close monitoring due to withdrawal; and has an extended release formulation that is 50% released immediately/50% delivered over time?

Dexmethylphenidate

What drugs are stimulants used to treat ADHD?

Amphetamine/dextromaphetamine mixed salts, methylphenidate, dextroamphetamine, amphetamine, methylphenidate

What ADHD drug has an adverse reaction of contact dermatitis with patch formulation?

Methylphenidate

What ADHD drug has a contraindication with pheochromocytoma and adverse reactions of abdominal pain, skin rash, urinary retention, and liver injury?

Atomoxetine

Which ADHD drug is not a controlled substance that would be good to use in a patient with history of drug abuse?

Atomoxetine

What drug has adverse drug interactions with QT prolongation and CYP2D6 substrates?

Atomoxetine

Which ADHD drugs are alpha-2 agonists?

Guanfacine and clonidine

Which ADHD drug has an adverse reaction of decreased appetite and should not be taken with a high fat meal or discontinued abruptly?

Guanfacine

Which ADHD drug does not cause weight loss or inhibit growth and would be good to give to a patient concerned about growth retardation?

Clonidine

Which drugs are non-stimulants used for the treatment of ADHD?

Atomoxetine, guanfacine, clonidine

Which drugs are able to be used in the treatment of ADHD, that are not stimulants or non-stimulants?

Bupropion, desipramine, imipramine

Which drugs used for narcolepsy have adverse reactions of Steven Johnson syndrome, nervousness, dizziness, rash, and diverse drug interactions with CYP inducers and QT prolongation?

Modafinil and armodafinil

Which narcolepsy drugs are alpha one agonists that are the standard of therapy for excessive daytime somnolence but do not treat cataplexy?

Modafinil and armodafinil

What narcolepsy drug is a CNS depressant with potent sedative hypnotic effects that is contraindicated for use with alcohol or other sedative hypnotics?

Sodium oxybate

What narcolepsy drug has adverse reactions of confusion, sleepwalking, and respiratory depression?

Sodium oxybate

What drug has a box warning for respiratory depression and adverse drug interactions with benzodiazepines and other CNS depressants?

Sodium oxybate

What drug improves excessive daytime somnolence, sleep paralysis, sleep hallucinations, cataplexy, and sleep architecture?

Sodium oxybate

What monoamine oxidase inhibitor can be used in the treatment of cataplexy in narcolepsy?

Selegiline

What drugs are first line for the treatment of excessive daytime sleepiness in narcolepsy?

Modafinil and armodafinil

What drugs are first line for the treatment of sleep paralysis, cataplexy, and hallucinations in narcolepsy?

Sodium oxybate