Lymphatic System (EXAM 1)

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65 Terms

1
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What are 3 important things to remember about 3 erythrocytes (RBC’s)?
* O2/CO2 transport
* Carry hemoglobin
* Anucleated
2
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What are 3 important things to remember about leukocytes (WBC’s)?
* Immune protection
* Don’t carry hemoglobin
* Nucleated
3
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List the different types of leukocytes
* Neutrophils
* Eosinophils
* Basophils
* Monocytes
* Lymphocytes (B cells & T cells)
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Neutrophils
* Most abundant WBC
* Anti-bacterial & anti-fungal phagocytes
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Eosinophils
* Anti-parasitic phagocytes
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Basophils
* Release of histamines
* Decreased heparin during allergic reactions causes increased inflammatory response
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Monocytes
* Travel and differentiate into macrophages
* Macrophages are large monocytes
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B cells
* Produce antibodies to attack specific foreign invaders
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T Cells
* Attack infected body and tumor cells
10
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Describe the structure of lymph fluid (plasma) within the lymphatic circulation
Present in:

* Capillaries


* Trunks
* Ducts
* Vessels
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Describe the structure of lymphoid organs and tissues
Present in

* Red bone marrow
* Thymus
* Lymph nodes
* Spleen
* Tonsils
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Describe the function of lymph fluid within the lymphatic circulation
* Drain excess ISF from blood capillaries
* Return fluid to the venous circulation
* Maintain body fluids/BV
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Describe the function of lymphoid organs and tissues
* Contain lymphocytes and other WBCs
* Detect the presence of foreign invaders/abnormal cells in lymph plasma or blood
* Initiate immune response
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What is significant about the primary lymphoid organs and tissues?
* The site where stem cells mature and become fully capable of initiating immune response
15
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Explain the red bone marrow and what it does
* Produces hemopoietic stem cells
* Differentiate into lymphoid stem cells
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What 2 cells stay in the RBM to fully mature?
* B cells
* NK cells
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Where do pre-T cells go to mature?
* Thymus
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What happens in the Thymus?
* Location where pre-T cells fully mature
* Either into Tc cells or Th cells
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What is the role of the secondary lymphoid organs and tissues?
* Location where lymphocytes activate immune response
* Help detect foreign invaders
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What are the 3 secondary lymphoid organs?
* Lymph nodes - filter lymph
* Spleen - Filter blood
* Tonsils - Monitor resp/digest. systems for inhaled/ingested materials
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Where are the tonsils located?
Within the nasopharynx
22
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What are the 3 different tonsils?
* Pharyngeal tonsil (above/behind oral cavity)
* Palatine tonsil (Back of mouth)
* Lingual tonsil (Back of tongue)
23
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Explain the location of the spleen
* Located in upper left abdomen
* Deep to diaphragm
* Lateral to stomach and pancreas
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What does the spleen contain?
* Splenic artery and vein
* Branches from abdominal aorta
* Drains into HPV
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What are the functions of the spleen?
* B, T cells, macrophages filter blood
* Remove old blood cells and platelets
* Produces, stores blood and platelets
* Clean blood exits splenic vein
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What is the outer capsule and trabeculae of a lymph node made of?
* Dense IR CT
27
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What is the lymph drainage from right breast to venous circulation?
* Lymph capillaries - Lymph vessels - mammary lymph nodes - efferent lymph vessels - bronchomediastinal trunk - R. lymph duct - R. brachiocephalic vein
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Quickly describe the innate immune system
* Immune response present @ birth
* Phagocytes consume pathogens
* Neutrophils, basophils, eosinophils, macrophages
* NK cells destroy infected/damaged cells
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Quickly describe the adaptive immune response
* Immune system developed over time
* Lymphocytes must recognize pathogens to illicit response
* T cells and B cells do this differently
* Produce memory cells
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What are the 3 innate first line defenses?
* Physical barrier
* Chemical Barriers
* Reflexes and processes
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What are the 2 main defenses used by the physical barrier?
* Skin
* Mucous membranes
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What are some chemicals used in the first line defenses?
* Saliva
* Gastric juices
* Sweat and oil
* etc.
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What are some reflexes and processes used in the first line of defense?
* Coughing/sneezing
* Urinating/defecating
* Vomiting
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What are the 2 second line defenses of the innate immune system?
* Phagocytosis
* Cytolysis
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What 3 leukocytes are active during phagocytosis?
* Neutrophils
* Monocytes
* “resident” macrophages
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What is the role of neutrophils during phagocytosis?
* Released in bloodstream and travel wherever needed
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What is the role of monocytes during phagocytosis?
* Released in bloodstream and travel wherever needed
* Not active cells
* Turn into “wandering” macrophages
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What is the role of “resident” macrophages during phagocytosis?
* Live in specific tissues
* Guard + protect in prep for microbes
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What is phagocytosis?
* Ingestion of microbe or cellular debris
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What is cytolysis?
* NK cells destroy infected/damaged cells
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What are the 4 steps of cytolysis?

1. Infected cells bind NK cells
2. NK cells release proteins (perfarins) to embed host cell
3. ECF flows through host cell
4. Host bursts
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What are the cardinal signs of inflammation?
* Pain
* Redness
* Immobility
* Swelling
* Heat
* (PRISH)
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What are the 3 stages of inflammation?

1. Vasodilation of arterioles
2. Emigration of Phagocytes to affected area
3. Tissue repair
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Explain the vasodilation of arterioles during inflammation
* Increase in permeability of capillaries
* Increased BF
* due to release of histamine from WBCs/damaged cell
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Explain the emigration of phagocytes during inflammation
* Neutrophils, macrophages
* move from blood to ISF
* dependent on chemotaxis
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Explain how tissue is repaired during inflammation
* Blood clotting
* Scar formation
* Epithelium regenerates
* Dependent on age, blood supply, nutrition
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What are the 2 different types of the adaptive immune system?
* Cell mediated
* Antibody mediated
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What antigens are recognized by the cell-mediated response?
* Abnormal cell
* Infected cell
* Cancerous/damaged cells
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What cells are involved in a cell-mediated response?
* APCs
* Th cells
* Tc cells
* Destroy Ags
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What antigens are recognized by the antibody-mediated response?
* Viruses
* Bacteria
* etc
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Where is the antibody-mediated response most active?
* Blood
* Lymph
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What cells are present in the antibody-mediated response?
* APCs
* B cells
* Turn into plasmocytes
* Secrete antibodies that destroy Ags
* Macrophages
* Th cells
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What are MHCs?
* Self antigens
* Embedded into membranes of all cells (except RBCs)
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What are the 2 classes of MHCs?
* MHC I
* All body cells (except RBCs)
* MHC II
* APCs
55
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Explain the presentation and recognition of exogenous Ags
* Located within blood or lymph
* Viruses, bacteria, etc
* Brought into APCs by phagocytosis
* Digested into fragments
* Bind to MHC II, then presented
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Explain the presentation and recognition of endogenous Ags
* Within cells
* Digested into fragments
* Binds to MHC I, then presented
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What does MHC stand for?
* Major histocompatibility complexes
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After Th cells bind to MHC II, what protein strengthens their binding?
CD4
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What cytokines are released after the APC binding to MHC II is complete?
* Tumor Necrosis Factor Alpha
* Interleukin-1
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What cytokine is released by active Tc cells?
* Interleukin-2
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After Tc cells bind to MHC I, what protein strengthens their binding?
CD8
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What cytokine being released by active Th cells activates costimulation?
* Interleukin-2
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What function creates pools of active and memory Tc cells?
* Clonal selection
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What do active Tc cells do?
* Leave lymph organ/tissue to circulate within the body
* Attack cells with Ag
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What do memory Tc cells do?
* Wait for next exposure to Ag
* Immune system is much better prepared for subsequent infection