* Immune system developed over time * Lymphocytes must recognize pathogens to illicit response * T cells and B cells do this differently * Produce memory cells
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What are the 3 innate first line defenses?
* Physical barrier * Chemical Barriers * Reflexes and processes
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What are the 2 main defenses used by the physical barrier?
* Skin * Mucous membranes
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What are some chemicals used in the first line defenses?
* Saliva * Gastric juices * Sweat and oil * etc.
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What are some reflexes and processes used in the first line of defense?
What cells are involved in a cell-mediated response?
* APCs * Th cells * Tc cells * Destroy Ags
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What antigens are recognized by the antibody-mediated response?
* Viruses * Bacteria * etc
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Where is the antibody-mediated response most active?
* Blood * Lymph
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What cells are present in the antibody-mediated response?
* APCs * B cells * Turn into plasmocytes * Secrete antibodies that destroy Ags * Macrophages * Th cells
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What are MHCs?
* Self antigens * Embedded into membranes of all cells (except RBCs)
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What are the 2 classes of MHCs?
* MHC I * All body cells (except RBCs) * MHC II * APCs
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Explain the presentation and recognition of exogenous Ags
* Located within blood or lymph * Viruses, bacteria, etc * Brought into APCs by phagocytosis * Digested into fragments * Bind to MHC II, then presented
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Explain the presentation and recognition of endogenous Ags
* Within cells * Digested into fragments * Binds to MHC I, then presented
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What does MHC stand for?
* Major histocompatibility complexes
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After Th cells bind to MHC II, what protein strengthens their binding?
CD4
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What cytokines are released after the APC binding to MHC II is complete?
* Tumor Necrosis Factor Alpha * Interleukin-1
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What cytokine is released by active Tc cells?
* Interleukin-2
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After Tc cells bind to MHC I, what protein strengthens their binding?
CD8
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What cytokine being released by active Th cells activates costimulation?
* Interleukin-2
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What function creates pools of active and memory Tc cells?
* Clonal selection
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What do active Tc cells do?
* Leave lymph organ/tissue to circulate within the body * Attack cells with Ag
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What do memory Tc cells do?
* Wait for next exposure to Ag * Immune system is much better prepared for subsequent infection