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Know the relationship between molecular weight and rate of diffusion The rate of diffusion is inversely proportional to the molecular weight Small weight-fast diffusion; heavy weight-slow diffusion Identify RBC’s in various solution and determine tonicity Tonicity - the ability of an extracellular solution to make water move into or out of a cell by osmosis If a cell is placed in a hypertonic solution, there will be a net flow of water out of the cell, and the cell will lose volume (shrink). A solution will be hypertonic to a cell if its solute concentration is higher than that inside the cell, and the solutes cannot cross the membrane. If a cell is placed in a hypotonic solution, there will be a net flow of water into the cell, the cell will gain volume (bigger). If the solute concentration outside the cell is lower than inside the cell, then solutes cannot cross the membrane, then the solution is hypotonic to the cell. If a cell is placed in an isotonic solution, there will be no set flow of water into or out of the cell, and the cell’s volume will remain stable. If the solute concentration outside the cell is the same as inside the cell, and the solutes cannot cross the membrane, the solution is isotonic to the cell. Homeostatic feedback loop for respiratory rate, heart rate and temperature Respiratory Rate: Stimulus : The level of carbon dioxide (CO2) in the blood increases (often due to exercise or hypoventilation) . Receptors: Chemoreceptors in the medulla oblongata, carotid arteries, and aortic arch detect changes in blood pH and CO2 levels Control Center: The medulla oblongata processes this information Effectors: Respiratory muscles (diaphragm and intercostal) adjust breathing rate and depth Response: Increased respiratory rate removes CO2 and increases O2 intake, restoring normal pH and gas levels. Heart Rate: Stimulus : Changes in blood pressure, O2, CO2, or pH levels Receptors: Baroreceptors (detect blood pressure changes) in the carotid sinus and aortic arch; chemoreceptors monitor blood chemistry Control Center: The medulla oblongata (cardiac center) processes signals Effectors : The autonomic nervous system (ANS) adjusts heart rate through the sympathetic nervous system (increases heart rate) or parasympathetic nervous system (decreases heart rate) Response : Heart rate increases during low O2 or low blood pressure (to circulate oxygen) and decreases when homeostasis is restored. Temperature Regulation Stimulus: Changes in body temperature (hyperthermia or hypothermia) Receptors: Thermoreceptors in the skin and hypothalamus detect temperature fluctuations. Control Center: The hypothalamus processes this information and signals effectors Effectors and Responses: If too hot: Blood vessels dilate (vasodilation) to release heat, and sweat glands produce sweat for cooling If too cold: Blood vessels constrict (vasoconstriction) to retain heat, and shivering generates warmth. Steps of a generic homeostatic feedback loop Stimulus : A change in the internal or external environment that disrupts homeostasis (eg. temperature change, pH levels, blood sugar levels) Sensor (Receptor) : Specialized cells or receptors detect the change and send information to the control center. Control Center (Integrator): Often the brain or endocrine glands, this component processes the information from the sensors and determines the appropriate response to restore balance. Effector: This component carries out the response to the stimulus as dictated by the control center. Effectors can be muscles or glands that help to counteract the change. Response: The action taken by the effectors to restore homeostasis. This could involve increasing or decreasing a physiological process (e.g. sweating to cool down or shivering to warm up) Feedback: The results of the response are monitored. If homeostasis is restored, the system maintains its state; if not, the loop may repeat, continuing to adjust until balance is achieved. How to evaluate data to determine the set point, error, and disturbance Identify the set point The set point is the optimal level or range that the system aims to maintain. To determine the set point: Gather baseline data: Collect data over a period to understand the normal range for the variable in question (e.g. body temp., BP, blood glucose levels) Analyze Trends: Look for patterns in the data to identify the average or median value that represents the stable condition of the system. Consult Literature: Reference established physiological norms or previous studies to confirm the typical set point for the variable. Assess Disturbance A disturbance is any factor or event that causes a deviation from the set point. To evaluate disturbances: Identify External and Internal Factors: Analyze the data for any external influences (e.g. environmental changes, dietary habits) or internal changes (e.g. illness, stress) that might have impacted the variable. Quantity Disturbance: Measure the magnitude and duration of the disturbance. This can be done by comparing the data points during the disturbance against the established set point. Monitor Changes: Track how the system responds to disturbances over time to assess their impact on maintaining homeostasis. WBC types and normal distribution values/ abnormal values and what those values indicate (infections/diseases) (Never Let Monkeys Eat Bananas) Neutrophils (50-70%) - First responders to infections, especially bacterial. High levels indicate bacterial infections, inflammation, or stress. Low levels can indicate bone marrow disorders or severe infections. Lymphocytes (20-40%) - Include B cells and T cells, important for immunity. High levels can suggest viral infections or leukemia, while low levels might indicate immune deficiency. Monocytes (2-8%) - Help with cleaning up dead cells and fighting infections. High levels can be linked to chronic infections or autoimmune diseases. Eosinophils (1-4%) - Involved in allergic reactions and fighting parasites. Elevated levels may indicate allergies or parasitic infections. Basophils (0.5-1%) - Release histamine during allergic reactions. High levels might be see in allergic conditions or blood disorders. Normal WBC Count Total WBC Count: 4000-11000 cells per microliter of blood (varies slightly by lab) Leukocytosis (High WBC): Can indicate infection, inflammation, stress, or leukemia Leukopenia (Low WBC): Can result from bone marrow disorders, viral infections, or autoimmune diseases Neutrophils: Banded vs Segmented Neutrophils are the most abundant type of white blood cells and play a crucial role in fighting infections. They exist in different stages of maturation: Banded Neutrophils (“Bands”) - Immature Neutrophils Appearance: Have a curved, unsegmented nucleus (band-shaped) Normal Range: 0-6% of total WBC count (~0-700/uL) Clinical Significance: Increased Bands (Bandemia) -> Indicates an acute bacterial infection or severe stress (e.g. sepsis). The bone marrow releases immature neutrophils in response to infection. Low Bands -> Not clinically significant unless the total WBC count is low, which could suggest bone marrow suppression. Segmented Neutrophils (“Segs”) - Mature Neutrophils Appearance: Have a segmented nucleus with 2-5 lobes Normal Range: 50-70% of total WBC count (~2500-7000/uL) Clinical Significance: High Segs (Neutrophilia) -> Suggests bacterial infections, stress, chronic inflammation, or leukemia Low Segs (Neutropenia) ->Can be caused by viral infections, bone marrow disorders, chemotherapy, or autoimmune diseases. Discuss the stages of cell cycle/mitosis-which stages are longest/shortest The cell cycle is a series of events that cells go through to grow and divide. It consists of two main phases: Interphase (Longest Phase) – Preparation for division Mitosis (Shortest Phase) – Actual cell division Stages of the Cell Cycle Interphase (90% of the Cell Cycle – Longest Phase) Interphase is the period of cell growth and DNA replication. It has three subphases: G1 Phase (Gap 1) The cell grows, produces proteins, and prepares for DNA replication. Longest variable phase; some cells may stay here indefinitely (e.g., neurons in G0 phase). S Phase (Synthesis) DNA replication occurs, ensuring each daughter cell gets a complete genome. Takes about 6-8 hours in human cells. G2 Phase (Gap 2) The cell prepares for mitosis by producing proteins and organelles. Shorter than G1 but still significant in length. Mitosis: Prophase, Metaphase, Anaphase, Telophase Know proportional and inversely proportional relationships Direct (Proportional) Relationship When two quantities increase or decrease together at a constant rate, they are directly proportional. Inversely Proportional When one variable increases, the other decreases proportionally. Know relationship between molecular weight and rate of diffusion The rate of diffusion of a substance is inversely proportional to the square root of its molecular weight. Lighter molecules diffuse faster Heavier molecules diffuse slower due to greater mass. Know relationship between filtration rate and pressure of fluid or weight of fluid Filtration rate is directly proportional to the pressure or weight of the fluid driving the filtration process. Higher pressure → Higher filtration rate Lower pressure → Lower filtration rate Know why men and women blood values are different The differences in blood values between men and women are due to biological, hormonal, and physiological factors
Updated 72d ago
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Let’s break this down! I’ll give you a study guide covering asexual reproduction, sexual reproduction (in humans and plants), and Mendelian genetics — then I’ll create a test for you. ⸻ Study Guide for Asexual Reproduction, Sexual Reproduction, and Mendelian Genetics ⸻ I. Asexual Reproduction • Definition: Involves a single parent, producing offspring genetically identical to the parent (clones). • Types of Asexual Reproduction: • Binary Fission: Simple cell division (e.g., bacteria). • Budding: New organism grows from a bud on the parent (e.g., yeast, hydra). • Fragmentation/Regeneration: Organism splits, and each part grows into a new organism (e.g., starfish). • Vegetative Propagation: New plants grow from parts of the parent plant (e.g., runners in strawberries). • Parthenogenesis: Offspring develop from unfertilized eggs (e.g., some lizards, insects). • Pros and Cons: • Pros: Fast, no need for a mate, energy-efficient. • Cons: No genetic variation, susceptible to environmental changes. ⸻ II. Sexual Reproduction (Humans & Plants) Humans: • Process: • Gametes (sperm and egg) produced by meiosis. • Fertilization forms a zygote (diploid cell). • Male Reproductive System: Testes, epididymis, vas deferens, prostate, urethra, penis. • Female Reproductive System: Ovaries, fallopian tubes, uterus, cervix, vagina. • Hormonal Regulation: • Male: Testosterone (sperm production, secondary characteristics). • Female: Estrogen & progesterone (menstrual cycle, pregnancy). Plants: • Process: Alternation of generations (sporophyte & gametophyte stages). • Pollination: Transfer of pollen to stigma. • Fertilization: Sperm (from pollen) fuses with egg in ovule. • Structures: Stamen (male), carpel/pistil (female). • Seed & Fruit Development: Fertilized ovules become seeds; ovary becomes fruit. ⸻ III. Mendelian Genetics • Gregor Mendel’s Experiments: Pea plants, discovered inheritance patterns. • Key Concepts: • Genes & Alleles: Genes determine traits, alleles are gene variants. • Dominant vs. Recessive Alleles: Dominant alleles mask recessive ones. • Homozygous vs. Heterozygous: Same alleles (AA or aa) vs. different alleles (Aa). • Laws of Inheritance: • Law of Segregation: Allele pairs separate during gamete formation. • Law of Independent Assortment: Genes for different traits sort independently. • Genetic Crosses: Punnett squares, monohybrid/dihybrid crosses. • Probability & Ratios: Phenotypic/genotypic ratios. • Non-Mendelian Inheritance: Incomplete dominance, codominance, multiple alleles, polygenic traits, sex-linked traits. ⸻ AP Biology Practice Test Total Questions: 30 (Multiple Choice) Section 1: Asexual Reproduction (6 questions) 1. Which form of asexual reproduction involves an organism splitting into two identical cells? a) Budding b) Fragmentation c) Binary fission d) Parthenogenesis 2. Which organism commonly reproduces through budding? a) Bacteria b) Starfish c) Hydra d) Fern 3. A disadvantage of asexual reproduction is: a) Slow reproduction rate b) High genetic diversity c) Vulnerability to environmental changes d) Requirement of a mate 4. Which plant structure is involved in vegetative propagation? a) Petal b) Stigma c) Runner d) Anther 5. Parthenogenesis involves: a) Fertilized eggs developing into offspring b) Unfertilized eggs developing into offspring c) Fusion of gametes d) Regeneration of lost body parts 6. What is the primary benefit of asexual reproduction in stable environments? a) Genetic variation b) Rapid population growth c) Evolutionary adaptability d) Reduced mutation rates ⸻ Section 2: Sexual Reproduction (8 questions) 7. In humans, fertilization typically occurs in the: a) Uterus b) Vagina c) Ovary d) Fallopian tube 8. The male gamete in plants is contained in the: a) Ovule b) Anther c) Pollen grain d) Stigma 9. Which hormone triggers ovulation? a) Testosterone b) Progesterone c) Luteinizing hormone (LH) d) Estrogen 10. The female gametophyte in flowering plants is the: a) Ovary b) Pollen tube c) Embryo sac d) Sepal 11. Which part of the male reproductive system produces sperm? a) Epididymis b) Vas deferens c) Testes d) Prostate gland 12. The process where pollen is transferred from anther to stigma is: a) Germination b) Pollination c) Fertilization d) Sporulation 13. What structure develops into a seed after fertilization in plants? a) Ovule b) Ovary c) Stamen d) Pistil 14. Which term describes the fusion of egg and sperm to form a zygote? a) Gametogenesis b) Meiosis c) Fertilization d) Pollination ⸻ Section 3: Mendelian Genetics (16 questions) 15. Who is considered the “Father of Genetics”? a) Charles Darwin b) Gregor Mendel c) Rosalind Franklin d) James Watson 16. The physical expression of a trait is called: a) Genotype b) Phenotype c) Allele d) Chromosome 17. An organism with the genotype Aa is: a) Homozygous dominant b) Homozygous recessive c) Heterozygous d) Diploid 18. A Punnett square shows: a) The process of DNA replication b) Possible genetic combinations of offspring c) Chromosome number in gametes d) Evolutionary relationships 19. The expected phenotypic ratio for a monohybrid cross is: a) 1:2:1 b) 9:3:3:1 c) 3:1 d) 4:0 20. Which of Mendel’s laws states that allele pairs separate during gamete formation? a) Law of Independent Assortment b) Law of Segregation c) Law of Dominance d) Law of Inheritance 21. Incomplete dominance results in: a) Blended traits b) Both traits expressed equally c) One trait completely masking another d) A 9:3:3:1 ratio 22. A cross between two heterozygous individuals (Aa x Aa) produces what genotypic ratio? a) 3:1 b) 1:2:1 c) 9:3:3:1 d) 2:2 23-30
Updated 85d ago
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Week 4 lect 1 Key Concepts from Steffen et al. (2015)** 1. **The Anthropocene**: - 2. **The Great Acceleration**: -u 3. **Planetary Boundaries**: - 4. ** ### **Key Insights from the Presentation: *Welcome to the Anthropocene***【11†source】 1. **Humans as a Dominant Force**: - The slides highlight that humans are no longer a temporary disturbance in Earth’s systems but have become one of the primary forces shaping ecological and geological processes. Humans now influence nearly all aspects of the biosphere, atmosphere, and hydrosphere. 2. **Scale and Speed of Change**: - The presentation underscores how the speed and scale of human-induced changes in the Earth system are unprecedented. The Anthropocene represents a significant shift, not just in terms of environmental change but also in how fast these changes are happening. 3. **Historical Context**: - It touches on how Earth’s climate has remained relatively stable throughout the Holocene, a period that allowed human civilization to flourish. However, there are concerns that we may be exiting this stable period into a more volatile future, similar to climates not seen in 50 million years. 4. **Debate on the Start of the Anthropocene**: - The slides mention the ongoing scientific debate over when exactly the Anthropocene began. Some argue for a start in 1610, tied to the Columbian Exchange and the resulting global environmental changes, while others suggest 1964, marked by the spike in radioactive isotopes from nuclear testing. 5. **Socio-Political Implications**: - The Anthropocene is not just a geological concept but also has deep socio-political ramifications. The presentation explores how this epoch is tied to issues of historical responsibility, colonialism, and global inequality. For instance, the environmental impacts of human activities are unequally distributed, with more significant contributions from developed countries. 6. **Future Challenges**: - The slides bring up important questions about sustainability and the future. How will humanity adapt to the environmental challenges posed by the Anthropocene, and what role will concepts like planetary boundaries play in guiding future actions? ### **Study Tips for the Exam**: - **Understand Key Terms**: Ensure you can define and explain terms like "Anthropocene," "Great Acceleration," and "planetary boundaries" clearly. - **Graphs and Data**: Be familiar with the socio-economic and Earth system trend graphs from the article. Recognize the key trends and be able to discuss their significance in the context of human-environment interactions. - **Connections Between Concepts**: Relate the idea of the Great Acceleration to the crossing of planetary boundaries and the wider implications for sustainability. - **Debates on Anthropocene's Start**: Prepare to explain the different views on when the Anthropocene began and the socio-political implications of each starting point. - **Global Inequalities**: Reflect on how the Anthropocene concept highlights disparities in environmental impact and responsibility between developed and developing nations. - **Sustainability Challenges**: Be ready to discuss the future of human societies in the Anthropocene, focusing on the role of international cooperation, climate negotiations, and adaptive strategies.
Updated 232d ago
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Cell Division and Reproduction Asexual Reproduction Only 1 parent required for asexual reproduction. Fast and simple process. Results in identical offspring without genetic variation. Examples include binary fission in bacteria. Sexual Reproduction Involves 2 parents contributing to offspring. Offspring genetically different from parents. Slower and more expensive compared to asexual reproduction. Leads to genetic variation, aiding evolution in changing environments. Modes of Reproduction Asexual reproduction involves a single parent producing genetically identical offspring through binary fission. Example: Amoeba divides by binary fission to form daughter cells. Sexual reproduction requires two parents contributing to genetically diverse offspring. Genetic variation in sexual reproduction allows adaptation to environmental changes. Eukaryotic Cell Division Mitosis produces identical daughter cells for asexual reproduction, growth, and repair. Meiosis generates different daughter cells for sexual reproduction and gamete formation. Meiosis results in four unique daughter cells compared to two identical cells in mitosis. Cell Cycle and Mitosis Eukaryotic Cell Division Mitosis results in daughter cells identical to the parent cell. Occurs in asexual reproduction, growth, development, and repair. Meiosis produces daughter cells different from parents for sexual reproduction. Involves the formation of gametes like sperm and egg. Eukaryotic Chromosomes Chromosomes are tightly coiled DNA structures. Human cells (except gametes) typically have 46 chromosomes. Genes are specific DNA sequences on chromosomes. Chromatin, a looser DNA form, condenses into chromosomes before cell division. The Cell Cycle Ordered sequence of events from cell formation to division. Consists of interphase (cell growth and DNA replication) and mitotic phase (DNA and cytoplasmic division). Interphase includes G1 (cell growth), S (DNA duplication), and G2 (preparation for division). Stages of Mitosis Prophase: Chromosomes coil tightly, spindles form. Prometaphase: Nuclear envelope breaks, microtubules attach to chromatids. Metaphase: Chromosomes align at the cell's equator. Anaphase: Sister chromatids separate and move to opposite ends. Telophase: Chromosomes decondense, nuclear envelope reforms. Cytokinesis: Cytoplasm divides, forming two daughter cells. Mitosis and Cell Division Mitotic Spindle Microtubules that separate chromosomes during mitosis. Aids in pulling DNA to opposite ends of the cell. Essential for proper chromosome distribution. Ensures accurate division of genetic material. Mitosis Summary Results in two daughter cells identical to the parent cell. Utilized in asexual reproduction, growth, and repair. Mathematically, chromosome count doubles during S phase and halves after cytokinesis. Ensures genetic stability and continuity in cell populations. Comparing Binary Fission and Mitosis Both processes involve chromosome duplication and cell division. Mechanics and timing differ between bacterial binary fission and eukaryotic mitosis. DNA replication and separation occur simultaneously in binary fission, unlike in mitosis. Mitotic spindle formation is unique to eukaryotic cell division. Cancer and Cell Cycle Cell cycle checkpoints regulate cell division. Disruption of checkpoints, like the G1/S checkpoint, can lead to cancer. Tumors result from uncontrolled cell growth. Benign tumors stay localized, while malignant tumors can metastasize. Eukaryotic Chromosomes and Cell Cycle Chromatin and Chromosomes Chromatin organizes DNA into chromosomes before cell division. Gene: a sequence of nucleotides on a chromosome. Sister chromatids are duplicated chromosomes held by a centromere. The Cell Cycle Phases Interphase: cell growth and DNA replication stages. Mitotic Phase: includes mitosis and cytokinesis for cell division. Mitosis stages: Prophase, Prometaphase, Metaphase, Anaphase, Telophase.
Updated 323d ago
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# Cram Study Guide ## Pre-European North American Societies 1. **Mississippian Culture** - Lived in the Mississippi River Valley. - Known for constructing large, earthen mounds and having a complex, hierarchical society. 2. **Iroquois Confederacy** - Located in the northeastern woodlands. - Consisted of five (later six) tribes, known for their matrilineal society and the political system of the Great Law of Peace. ## “Do Glaciers Listen?” - The phrase refers to the impact of environmental changes on human societies and how human activities are affected by natural phenomena like glaciers. It suggests a dynamic relationship between nature and human culture. ## Mesoamerican Reverence for Astronomers - Mesoamericans revered astronomers for their ability to predict celestial events, which were crucial for agricultural cycles and religious ceremonies. Astronomers held significant power due to their knowledge. ## Mesoamerican Empires 1. **Maya** - Known for their advanced writing system, mathematics, and astronomical knowledge. 2. **Aztec** - Renowned for their massive capital, Tenochtitlan, and their powerful empire in central Mexico. ## West African Nations Prior to 1492 1. **Mali Empire** - Famous for its wealth, particularly under Mansa Musa, and its vibrant trade networks. 2. **Songhai Empire** - Known for its control of trans-Saharan trade and its capital, Gao, as a center of learning and culture. ## Commercial Revolution and Nation States - The Commercial Revolution involved increased trade and the rise of banking and joint-stock companies, which led to the accumulation of wealth and the centralization of power, fostering the development of nation-states in Europe. ## First European Nation State to Colonize America - **Spain** was the first to establish colonies in America, starting with Christopher Columbus's voyages in 1492. ## Non-Human Environmental Factors in Colonization 1. **Disease** - Indigenous populations were decimated by diseases like smallpox brought by Europeans. 2. **Climate** - The Little Ice Age impacted agricultural productivity and settlement patterns. ## Jamestown Colony - Established in 1607 by the Virginia Company. - Goals included searching for gold and establishing trade routes. - Characterized by harsh conditions, high mortality rates, and eventual success with tobacco cultivation. ## New England Puritans - Mission: To create a "city upon a hill," a model of religious virtue and piety. - Theology: Predestination, the importance of a covenant community, and strict moral codes. ## John Winthrop’s ‘City on a Hill’ - John Winthrop envisioned the Puritan colony as a model of Christian charity and righteousness that would inspire others and demonstrate God's favor. ## Non-Warfare European & Indian Interactions 1. **Trade** - Exchange of goods like furs and European manufactured items. 2. **Alliances** - Formed for mutual defense and economic benefit. 3. **Intermarriage** - Led to cultural exchanges and mixed communities. ## African vs. American Slavery - African slavery often involved captives from wars, debtors, or criminals and was generally not hereditary. - American slavery was racial, hereditary, and brutal, focusing on lifelong bondage and dehumanization. ## Changes in Puritan Theology on the Frontier - Puritan theology became more individualistic and less strict as it spread to the frontier, adapting to the challenges of frontier life and contact with diverse cultures. ## Royal African Company - In the 1700s, it had a monopoly on the British slave trade, facilitating the transportation of enslaved Africans to the Americas and significantly impacting the British economy. ## Seven Years War Consequences - Britain gained vast territories in North America. - The war debt led to increased taxation of American colonies, fueling discontent and eventual revolution. ## Factors for American Independence 1. **Taxation Without Representation** - Colonists resented taxes imposed by a distant parliament without their consent. 2. **British Military Actions** - Events like the Boston Massacre and harsh measures like the Intolerable Acts. ## Reconquista’s Impact on Spanish Conquest - The Reconquista fostered a militant Catholicism and a mindset of conquest and conversion, influencing Spanish approaches in the New World. ## Bartolome de Las Casas’ Argument - De Las Casas argued that Spain's treatment of indigenous people was inhumane and advocated for their rights and better treatment. ## John Smith’s Narrative of Pocahontas - Revealed aspects of Powhatan culture, such as political alliances, kinship, and the complexity of Native American societies. ## Social Changes from the Great Puritan Migration - Led to the establishment of a new, religiously motivated society in New England with significant impacts on local governance, community structure, and relations with Native Americans. ## Roger Williams & Anne Hutchinson - Their narratives reveal the strictness and intolerance of dissent within Puritan culture, leading to their banishments and the founding of more tolerant colonies. ## Bacon’s Rebellion Causes and Consequences - Caused by frontier settlers' frustrations with colonial government policies and lack of protection from Native American attacks. - Resulted in increased tensions between wealthy planters and poorer settlers, and a shift towards African slavery. ## Phillis Wheatley’s Poetry - Challenged Anglo views by demonstrating the intellectual capabilities and humanity of African Americans, contributing to anti-slavery sentiments. ## Jonathan Edwards’ “Sense of the Heart” - Described a deep, personal experience of God’s grace and presence, emphasizing emotional and spiritual transformation. ## George Whitfield’s Revivals - His evangelical revivals democratized religion, appealing to marginalized groups and fostering a sense of equality and personal empowerment. ## Thomas Paine’s “Common Sense” - Galvanized American public opinion in favor of independence with its clear arguments against monarchy and for self-governance. ## Mercantilism and Colonial Conflict - Mercantilism’s emphasis on accumulating wealth through colonies led to restrictive trade policies, causing resentment and economic strain in the colonies. ## Columbian Exchange Transformations - Brought new crops and livestock to Europe and the Americas, transforming diets and agricultural practices, but also led to the spread of diseases. ## Great Awakening’s Impact on Identity - Fostered a sense of shared American identity, as colonists experienced a religious revival that emphasized personal faith and questioned traditional authority. ## Charles Woodmason’s “Mixed Medley” - Described the diverse and often unruly nature of Carolina frontiersmen, reflecting the challenges of colonial governance and social order. ## Anglo/Indian Trade Impact - Altered Native societies, introducing new goods and dependencies, but also creating new economic opportunities and alliances. ## Virginia Resolves Argument - Asserted that only the Virginia Assembly had the right to tax Virginians, challenging Parliament’s authority and laying groundwork for revolutionary thought. ## Parliament’s Response to Non-importation - Attempts to suppress colonial resistance through punitive measures only fueled further discontent and unified the colonies against Britain. ## Stono Rebellion Insights - Revealed the harsh conditions and resistance of enslaved Africans, highlighting the brutality of American slavery and the desire for freedom. ## Imperial Wars’ Impact on Relations - Strained colonial resources and fostered resentment towards Britain, contributing to a growing sense of American identity and independence. ## Lord Grenville’s Fiscal Policies 1. **Sugar Act** - Imposed taxes on sugar and molasses, affecting colonial trade. 2. **Stamp Act** - Required stamped paper for legal documents, inciting widespread protests. ## Stamp Act Congress and ‘British’ Identity - Showed colonial unity and a collective identity as British subjects demanding their rights, laying the foundation for coordinated resistance. ## Boston Massacre Trial - Exposed conflicting views: some saw it as a symbol of British tyranny, while others viewed it as a tragic misunderstanding, reflecting broader social tensions. ## 1st Continental Congress on Independence - Sought to address grievances and restore colonial rights within the British Empire, rather than immediate independence, reflecting a cautious approach. ## King George III’s Lexington & Concord Response - His decision to use military force solidified colonial opposition, leading to wider conflict and the push for independence. ## Unit One Essay Prompts ### European Expansion - **Driving Forces:** Economic motives (gold, trade routes), religious zeal (spread Christianity), and competition among European powers. - **Ideological Origins:** The Reconquista’s militant Catholicism, the Renaissance’s spirit of exploration, and mercantilist policies. - **Columbian Exchange:** Introduced new crops and animals to both worlds, spread diseases, and reshaped economies and cultures. ### English Colonial Society (1607-1740) - **Key Factors:** Economic opportunities, religious freedom, and political ambitions. - **Changes:** Growth of plantation economies in the South, development of urban centers in the North, and increased conflict with Native Americans. - **Conflicts:** Bacon’s Rebellion, religious dissent in New England, and tensions over land and resources. ### Imperial Wars & Great Awakening - **Relationship:** Wars strained colonial resources and governance, while the Great Awakening unified colonists through shared religious experiences. - **Changes in Colonies:** Increased diversity, economic growth, and social stratification. - **Evangelism:** Leaders like Jonathan Edwards sought to revive faith, contributing to a sense of identity and mission among marginalized colonists. ### American Revolution Causes - **Declaration of Independence:** Resulted from taxation without representation, British military actions, and the desire for self-governance. - **Independence Popularity:** Varied; strong support in some areas, but Loyalist opposition existed. - **Divisions:** Social, economic, and political differences highlighted the complexity of unifying diverse colonies. --- This study guide covers key points and questions, providing a foundation for deeper study and understanding of each topic.
Updated 328d ago
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1.3 Macro Intro Breaking a bond = hydrolysis Build/make a bond = remove water, dehydration synthesis 1.4 Macros Nucleic Acids DNA and RNA Made from nucleotides A, T, C, G, U Proteins Amino acids Polypeptide To make it into a protein you need to fold and modify Carbs Monosaccharides Ex. glucose Polysaccharides Ex. starch, cellulose, glycogen, chitin Lipids nonpolar Ex. phospholipids Saturated (butter) vs unsaturated (oil) 1.5 Macros structure + function Uses covalent bonds between nucleotides Main structure want it to be covalent bond so its strong Bases use hydrogen bonds DNA is antiparallel, equally spaced read in opposite directions Protein Primary - Amino acids Secondary - Pleats and coils (hydrogen bonding) Tertiary - Interactions between the R-groups (unique shapes) Quaternary - 2 or more chains (any bond) Carbs Chains of sugars using covalent bonds 1.6 Nucleic Acids DNA Deoxyribose sugar T Double stranded RNA Ribose sugar U Single stranded Common Both use nucleotides A, G, C U2 Cells Organelles Ribosomes = protein synthesis Found on rough ER or free Show common ancestry Endoplasmic Reticulum Rough = ribosomes Smooth = makes lipids, detox Golgi complex Protein trafficking Packaging and transport of proteins mitochondria Site of cellular respiration, ATP production Double membrane Own DNA circular DNA Chloroplast Site of photosynthesis Own circular DNA Lysosome Hydrolytic enzymes Apoptosis Vacuole Large in plants Small in animal cells 2.3 Cell Size Small cells Inc surface area to volume ratio More efficient Better for transportation, elimination of waste, heat, exchanges, etc 2.4 Plasma Membrane Small and nonpolar can pass through easily (oxygen and carbon dioxide) 2.5 Membrane Permeability Selectively permeable Transport proteins needed for larger polar molecules Cell wall - plants, fungi, and prokaryotes Provides extra support and protection 2.6 Transport Passive transport (high to low) Does Not require any energy Diffusion Osmosis Facilitated diffusion (uses proteins) Active transport (low to high) Require energy Exocytosis Moving things in or out Endocytosis 2.7 Facilitated diffusion Uses integral proteins Ex. aquaporins, ion channels, neurons Proteins also used for active transport 3.6 Cellular Respiration Glycolysis Within the cytoplasm Evidence of common ancestry because all organisms go through glycolysis Glucose to 2 pyruvates Energy investment phase and energy payoff phase Get pyruvate, ATP, and NADH Fermentation (ONLY IF NO OXYGEN) To reset everything Takes NADH and turns it back to NAD+ to keep running glycolysis Grooming Phase Modify and turn it into Acetyl CoA Kreb Cycle With in the matrix Making electron carriers (NADH and FADH2) Inner mitochondrial membrane Where the electron transport chain takes place 3.7 Fitness Max offspring Variation can increase fitness Unit 4 Cell Communications 4.1 Signal Transduction Pathway Autocrine (signal yourself) Paracrine (next to you) Endocrine (far from you) 4.2 Signal Transduction Pathway intro Reception → transduction → response Reception: ligand attacks to the receptor The process by which a cell detects a signal in the environment. Ex. ligand binds to G protein which activates Transduction: phosphorylation cascade and amplifies signal The process of activating a series of proteins inside the cell from the cell membrane. Response: The change in behavior that occurs in the cell as a result of the signal. Second messenger - first is ligand, second messenger is for amplification (cAMP - each can have their own phosphorylation cascades) 4.3 STP Responses Turn gene off/on Apoptosis Cell growth start/stop 4.4 changes to STP Mutations (respond too much or too little to the signal molecule attacking) Chemical can release that can interfere with your STP resulting with death 4,5 Feedback Respond to changes (homeostasis) Negative (reverse change) Positive (increasing the change) 4.6 / 4.7 Cell Cycle/ Regulation G1 - growth G1 checkpoint (determine if you go to S phase or to G0 non dividing state) S - DNA replication G2 - organelle replication and growth G2 checkpoint - make sure the cell is ready for division M phase - Mitosis PMAT Prophase - nucleus disappears Metaphase - lined up at the equator Anaphase - replicated chromosomes are split Telophase - move to opposite ends M-phase checkpoint - checks to make sure division is correct Cytokinesis - final split into 2 Cyclin increases during S and peaks at M Cdk binds with cyclin to produce mpf Level of cyclins lets cell know where it’s supposed to be Tells your cell you are at your full maturity ready to produce Unit 5 Heredity 5.1 / 5.2 Meiosis Increases genetic variation Crossing over (Prophase 1) Reduction division haploid (half the amount of genetic information) Random fertilization Nondisjunction (meiosis 1 all 4 cells are irregular / meiosis 2 half the cells are irregular) Independent Assortment Increases genetic diversity 5.3 Mendelian Genetics A = dominant allele a = recessive allele Genotype - combination of letters (AA, Aa, aa) Phenotype = looks Law of Segregation - Aa → A / a Law of Independent Assortment (Aa Bb → AB, Ab, aB, ab) Sex Linked Located on a sex chromosome Usually X Sex linked recessive is more common in males because they only have one X Sex linked dominant both can inherit easily Incomplete dominance - blending Codominance - both alleles expressed 5.5 Environmental Effects Ex. weather, pH of soil 5.6 Chromosomal Inheritance Mutation → inherited Some have no effect, negative effect, neutral effect, 6.1 Gene Expression and Regulation 6.1 DNA Double stranded Deoxyribose T RNA Ribose Single stranded U 6.2 Replication (S-Phase) 5’ → 3’ Ligase - binds the new bases together Helicase - unwinds the DNA DNA poly - put down the new bases Primase - makes primer Topoisomerase - stops DNA from getting overwind Leading - able to all go in one go Lagging - many primers and okazaki fragments 6.3 Transcription and Processing Nucleus RNA poly makes primary transcript (pre mRNA) from DNA Template strand is the one the DNA is using to build Non template strand one not being used RNA processing Introns are removed Exons are put together Add cap and tail for protection Alternative splicing 6.4 Translation Ribosome Reverse Transcriptase retroviruses Ex. HIV RNA genomes use reverse transcriptase to make DNA from RNA 6.5 Regulation of Gene Expression Signal to unpack the gene Transcribed (transcription factors differ by cells and allows different gens to turn on) RNA editing Translation Polypeptide folding All need to go correctly or else the gene wont be expressed Acetylation of histones - adding acetyl group causes the DNA to be more loose making it easier to read Methylation of histones - adding methyl groups to the DNA causes it to be tighter and harder to read Enhancers - enhances transcription and causes it to occur more often Activators - dont bind to RNA poly it binds to the enhancer Depends of which genes and stage of development Epigenetics - one gene controls another gene Inducible Operon - usually off Repressor is bound to operon and lactose inactivates Repressible Operon - usually on Repressor is usually inactive, trp activates repressor 6.6 Gene Expression and Cell Specialization Promoter region (TATA box) alerts RNA poly that its a promoter region and where to attach Negative regulation - blocks promoter so RNA poly cant attach small RNA - can turn certain genes off 6.7 Mutations Increase normal gene function Decrease normal gene function Can lead to new phenotypes Cancer can be due to overproduction of growth factors, hyperactive proteins (requires many mutations Can have positive, negative, or no effect Causes of mutation Exposures Random Errors in DNA replication Increase or decrease in chromosome number Prokaryotes Transformation - pick up random DNA Transduction - virus accidentally is filled with bacterial DNA Conjunction - mating bridge/sex pilus 6.8 Biotechnology Electrophoresis - separates DNA by charge and size PCR - artificial DNA replication, increases amount of DNA sample Transformation - you make the bacteria take up a gene you're interested in Unit 7 7.1 Natural Selection natural / selective pressures decide survival Reproductive fitness (max out your kids) 7.2 Natural Selection Acts on phenotypes which can affect genotype Preferring brown fur over white decreases white fur allele frequency Environmental changes → selective pressures 7.3 Artificial Selection Humans select (ex. Dogs, livestock, etc) Convergent evolution - not closely related but because of similar environments you look alike Divergent - had a recent common ancestor but you started becoming separate Niche partitioning - choosing separate niches so you dont have to compete with others 7.4 Population Genetics Mutation - variety and evolution Genetic drift - random event that alters the gene pool Bottleneck effect - an event causes a large part of the population to die off and the remaining left repopulate with a different gene pool Founder effect - the og are there but some leave/get separated 7.5 Hardy Weinburg Large population No natural selection Random mating No mutation No gene flow P+q = 1 p2 + 2pq +q2 = 1 (AA) + (Aa) + (aa) = 1 7.6 Evidence of Evolution Fossils DNA (molecular homologies) Anatomy Vestigial structure (things we dont need anymore) (evidence of common ancestry) Biogeography (species are found all around the world)(kangaroos, genetic code, glycolysis) 7.7 Common Ancestry All Eukaryotes Membrane bound organelles Linear DNA and chromosomes Genes with introns 7.8 Continuing Evolution Genomic changes over time Continuous changes in fossils Evolution of antibiotic resistance Disease evolution 7.9 Phylogeny / Cladistics Phylogeny = included time Cladograms = just traits Shared characters Derived characters Molecular (DNA, proteins, amino acids) are more accurate than characteristics Parsimony - the one with the fewer events on it, the frewer you have the more likely it is 7.10 Speciesation Pre-zygotic Mechanical - parts dont match Gametic - egg doesnt match Geographical - dont live in the same place Temporal - ready to mate at different times Behavioral - specific type of mating display is not there Post-zygotic Hybrid sterility - the hybrid made is healthy but they cannot have children (mule) Hybrid breakdowns - the hybirds are okay but after a generation or two they cannot produce anymore Hybrid inviability - hybrid is produced but cannot survive long enough to reproduce Sympatric New species arrises in the original location Gradualism - slow steady evolution Allopstric Separation leads to speciation Punctuated - long periods of evolution with no change then rapid change 7.11 Extinction Can be natural or human caused If something goes extinct it can open up opprotunities for other species 7.12 Variation Genetic diversity Diversity of the ecosystem = inc biodiversity Less likey to be 7.13 Origins of Life on Earth No oxygen on earth 4.6 billion No ozone layer Tons of UV radiation High ocean levels Vooacanic eruptions RNA was the first genetic material DNA is dependant of RNA in
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