Do Sperm entry
Dorso-ventral Axis
cortical rotoute
micro mebies
مسا
e99
TOSH
>
Beast
SIOu
by cortica voters
transport
proteins
on microtuble
B-catenin activation occurs due to Wrt signaling
B-catenin →nodal → organizer related high
D
- B-catenin in dorsal nuclei
vegT, vg|
I nodal →
related low
ventral mesoderm
Epidermal vs Neural Fate
BMPs: early signals that influence ectodermal cells
→ High BMP = epidermal differentation
→ low BMp= neural difterentation
Noggin, Chordin, Follistatin bind and inhibit BMP → blocks the induction of nueral tissues, maral
instructive signal by the
→ permissive induction: removal of EMP
_]
> Spemann's organizer releases BMP inhibitors
Wnts: paten the neural plate to be anterior -posterior → cerberus, FrzB, DickkopF
• cerberus & ErzB → bind & inhibi+ Wrts
Dickkopf → Bind to receptors