đ Chapter 19: Blood â Full Simplified Study Notes (27 Slides)
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Slide 1: Cardiovascular System
⢠Cardiovascular system = heart, blood, blood vessels.
⢠Bloodâs job:
⢠Delivers nutrients, hormones, oxygen, and chemical messages.
⢠Carries immune cells to fight infections.
⢠Why it matters: Without this transport system, cells would starve and toxins would build up.
⢠Analogy: Like UPS + garbage service â delivers packages (nutrients, Oâ) and removes trash (waste, COâ).
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Slide 2: Whole Blood
⢠Whole blood = plasma + formed elements.
⢠Hematocrit: percentage of blood volume made of cells.
⢠Plasma: watery fluid.
⢠Key properties of blood:
⢠Temp: 38°C (100.4°F) â warmer than body surface.
⢠Thickness: 5x thicker than water.
⢠pH: ~7.4 (slightly alkaline).
⢠Volume: Men = 5â6 L, Women = 4â5 L.
⢠About 7% of body weight.
⢠Example: If someone weighs 150 lbs, about 10 lbs of that is blood.
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Slide 3: Blood Plasma
⢠Plasma = liquid with proteins + solutes.
⢠Proteins:
⢠Albumins: keep water inside blood vessels (prevent swelling).
⢠Globulins: antibodies â defense.
⢠Fibrinogen: forms clots.
⢠Other solutes:
⢠Electrolytes: Naâş, Kâş, Clâť, HCOââť (important for nerves/muscles).
⢠Nutrients: glucose, fructose, amino acids.
⢠Wastes: urea, uric acid.
⢠Analogy: Plasma = soup broth carrying salt, sugar, proteins, and waste.
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Slide 4: Formed Elements
⢠Red Blood Cells (RBCs / erythrocytes): 99.9% of all blood cells.
⢠RBC count: Men = 4.5â6.3 million/ÎźL, Women = 4.2â5.5 million/ÎźL.
⢠Platelets: fragments needed for clotting.
⢠White Blood Cells (WBCs / leukocytes): fight disease.
⢠Think: Plasma is the liquid, formed elements are the âstuff floating inside.â
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Slide 5: RBC Structure
⢠RBCs lose their nucleus & organelles.
⢠Consequences:
⢠Canât divide.
⢠Canât make proteins or repair.
⢠Only use glycolysis (anaerobic metabolism) â no oxygen needed for energy.
⢠Analogy: Like delivery trucks with no engine shop â they drive until they break down.
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Slide 6: RBC Lifespan
⢠RBCs have no nucleus, mitochondria, ribosomes â no repair.
⢠Rely on glycolysis for energy.
⢠Live about 120 days.
⢠Must be recycled by spleen/liver.
⢠Example: Like a disposable battery that runs until it dies.
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Slide 7: RBC Shape & Function
⢠Shape = biconcave disc (doughnut-like, thin middle).
⢠Benefits:
⢠High surface area â better oxygen exchange.
⢠Can stack like coins â smooth flow.
⢠Flexible â squeeze through tiny capillaries.
⢠Analogy: Like a flexible frisbee that can bend and stack.
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Slide 8: Hemoglobin
⢠Main protein inside RBC.
⢠Structure:
⢠2 alpha chains + 2 beta chains.
⢠Each has heme group with iron atom (Fe).
⢠Function: Iron binds oxygen â carries it around body.
⢠Why recycle? Iron is valuable, so old RBCs get broken down to save it.
⢠Analogy: Hemoglobin = oxygen backpack.
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Slide 9: RBC Lifecycle
⢠Starts from hemocytoblast (stem cell).
⢠Branches into:
⢠Myeloid stem cells: make RBCs + some WBCs.
⢠Lymphoid stem cells: make lymphocytes.
⢠Think: Hemocytoblast = tree trunk, RBCs and WBCs = branches.
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Slide 10: RBC Production (Erythropoiesis)
⢠Erythropoiesis = making RBCs.
⢠Embryo: 1st 8 weeks = yolk sac â later liver, spleen, thymus, bone marrow.
⢠Adult: red bone marrow only (vertebrae, sternum, ribs, skull, pelvis, ends of long bones).
⢠Nutrients needed: amino acids, iron, vitamins B12, B6, folic acid.
⢠Analogy: RBCs = cookies, bone marrow = kitchen, iron + vitamins = ingredients.
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Slide 11: RBC Production Control
⢠Controlled by erythropoietin (EPO).
⢠Made by kidneys/liver when low oxygen (hypoxia).
⢠Effects:
⢠Increases stem cell division.
⢠Speeds up hemoglobin production.
⢠Blood doping: Athletes take EPO or reinfuse RBCs â more oxygen for muscles.
⢠Risk: thicker blood â clots, strokes.
⢠Analogy: EPO = coach yelling âmake more RBCs!â
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Slide 12: Blood Types
⢠RBCs have antigens on membranes (A, B, AB, O).
⢠Rh factor = + or â.
⢠Plasma has antibodies (agglutinins): attack foreign antigens â cause clumping (agglutination).
⢠Universal donor = Oâ.
⢠Analogy: Blood type = ID card. If ID doesnât match, antibodies attack.
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Slide 13: RBC Summary
⢠Know:
⢠How typing works.
⢠How RBCs are made.
⢠What controls them.
⢠Why they live 120 days.
⢠How theyâre broken down.
⢠Analogy: RBCs = delivery trucks with expiration dates.
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Slide 14: WBC Basics
⢠WBCs = leukocytes.
⢠Have nuclei, organelles, no Hb.
⢠Functions: fight pathogens, remove wastes, destroy abnormal cells.
⢠Only in blood briefly â then move into tissues.
⢠Analogy: WBCs = bodyâs police force.
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Slide 15: Neutrophils
⢠50â70% of WBCs.
⢠Nucleus 2â5 lobes.
⢠First responders â attack bacteria.
⢠Use phagocytosis + enzymes.
⢠Die quickly â pus = dead neutrophils + bacteria.
⢠Analogy: Neutrophils = foot soldiers.
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Slide 16: Basophils
⢠<1% WBCs.
⢠Release histamine (dilates vessels, causes swelling/redness).
⢠Release heparin (prevents clots).
⢠Trigger inflammation â work with mast cells.
⢠Analogy: Basophils = fire alarms.
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Slide 17: Eosinophils
⢠2â4% WBCs.
⢠Stain red-orange.
⢠Bi-lobed nucleus.
⢠Kill parasites, respond to allergies.
⢠Release toxic chemicals (nitric oxide, enzymes).
⢠Help control inflammation.
⢠Analogy: Eosinophils = exterminators.
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Slide 18: Monocytes
⢠2â8% WBCs.
⢠Largest WBC, kidney-shaped nucleus.
⢠Become macrophages in tissue.
⢠Eat large pathogens, dead cells.
⢠Call fibrocytes â scar tissue.
⢠Analogy: Monocytes = garbage trucks.
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Slide 19: Lymphocytes
⢠20â30% WBCs.
⢠Big nucleus, little cytoplasm.
⢠Most live in lymph tissue.
⢠Types:
⢠T cells: attack infected cells.
⢠B cells: make antibodies.
⢠NK cells: kill cancer/virus cells.
⢠Analogy: Lymphocytes = special forces.
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Slide 20: WBC Production
⢠From hemocytoblasts.
⢠Myeloid stem cells: all except lymphocytes.
⢠Lymphoid stem cells: lymphocytes.
⢠Colony-Stimulating Factors (CSFs):
⢠M-CSF = monocytes.
⢠G-CSF = granulocytes.
⢠GM-CSF = granulocytes + monocytes.
⢠Multi-CSF = RBCs + WBCs + platelets.
⢠Analogy: CSFs = managers assigning jobs.
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Slide 21: Platelets
⢠Fragments of cells, no nucleus.
⢠Lifespan = 9â12 days.
⢠Removed by spleen.
⢠2/3 stored for emergencies.
⢠Analogy: Platelets = emergency patch kits.
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Slide 22: Platelet Functions
1. Release clotting chemicals.
2. Form platelet plug at damage site.
3. Contract (actin + myosin) â shrink clot, close wound.
⢠Analogy: Platelets = patch team pulling duct tape tight.
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Slide 23: Hemostasis
⢠Definition: stopping bleeding.
⢠3 phases: vascular, platelet, coagulation.
⢠Analogy: Like fixing a leaking pipe step by step.
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Slide 24: Vascular Phase
⢠Vessel wall contracts (vascular spasm).
⢠Endothelial cells:
⢠Expose basement membrane.
⢠Release endothelins â stimulate contraction/healing.
⢠Become sticky â platelets attach.
⢠Analogy: Pinch a hose to slow the leak.
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Slide 25: Platelet Phase
⢠Platelets stick to exposed collagen.
⢠Form platelet plug (15 sec after injury).
⢠Release chemicals: ADP, thromboxane Aâ, serotonin, Ca²âş, PDGF.
⢠Feedback prevents over-clotting.
⢠Analogy: Like putting your hand over a hole until repair arrives.
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Slide 26: Coagulation Phase
⢠Chain reaction of clotting factors.
⢠Fibrinogen â fibrin (forms net).
⢠Common pathway:
1. Factor X â prothrombinase.
2. Prothrombin â thrombin.
3. Fibrinogen â fibrin.
⢠Clot retraction pulls vessel edges together.
⢠Analogy: Casting a fishing net over the leak.
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Slide 27: Fibrinolysis & Clotting Needs
⢠Fibrinolysis: clot dissolves after healing.
⢠t-PA â activates plasminogen â plasmin â digests fibrin.
⢠Requirements for clotting:
⢠Calcium (Ca²âş): needed in all clotting steps.
⢠Vitamin K: liver makes clotting factors; comes from food + gut bacteria.
⢠Deficiency = bleeding problems.
⢠Analogy: Once pipe is repaired, cut away the net (clot)
Updated 14d ago