mature lymphoid neoplasms chapter 34

primary site of disease for leukemias

blood or bone marrow

primary site of disease for lymphomas

lymph nodes or spleen

what is the gold standard for lymphona diagnosis

excisional biopsy

what is the most common leukemia in adults in western countries

chronic lymphocytic leukemia

chronic lymphocytic leukemia (CLL) morphology

smudge cells (basket cells)

which protein can you add to help preserve the lymphocyte cell wall from rupturing

albumin

B cell phenotyping

CD19 + CD20

prolymphocytic leukemia (PLL) characteristic

>50% prolymphocytes

hairy cell leukemia characteristics

small B lymphs with abundant cytoplasm and fine ‘hairy’ cytoplasmic projections

which stain is specific for HCL

TRAP stain(tartrate resistant acid phosphate)

burkitt lymphoma/leukemia characteristic

basophilic cytoplasm with distinct vacuoles (starry night)

mycosis fungoides (MF)/sezary syndrome is a ___ lymphoma

T cell

most common form of cutaneous T cell lymphoma

MF

MF/SS morphology

cerebral formed nucleus

anaplastic large cell lymphoma is a ___ disorder

T cell

monoclonal gammopathy of undetermined significance (MGUS) is ___

benign

multiple myeloma (MM) characteristics

>70% plasma cells in bone marrow, bence jones protein positive

MM peripheral blood morphology

rouleaux

which immunoglobulin is elevated in MM

IgG

which immunoglobulin is elevated in waldenstrom’s macroglobulinemia

IgM

what is an M spike

a spike in the gamma region in protein electrophoresis

hodgkins lymphoma (HL) affects which age group

young adults

HL morphology

reed sternberg cells, ‘owl eye’

hodgkins lymphoma

multiple myeloma bone marrow

mycosis fungoides/sezary syndrome MF/SS

burkitt lymphoma/leukemia (BL)

hairy cell leukemia (HCL)

chronic lymphocytic leukemia (CLL)