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microscopy
discovery of the very small
Robert Hooke
published micrographia in 1665
Anton con Leeuwenhoek
skilled in grinding lenses that allowed him to see in x200 & described "animalcules" in a specimen of a lake water
What are microorganisms?
naked to human eye, can be fungus, bacteria, virus, & archea
1600's vitalists thought...
life generated spontaneously from decaying materials
Leeuwenhoek's belief
BELIEVED IN SPONTANEOUS GENERATION
maggots arose from eggs in the decaying material, not from the material itself
Francesco Redi belief
if flies were prevented from landing on meat, it didn't produce maggtos
Francesco Redi's experiment
2 mason jars, one covered = no maggots
Louis Pasteur discredited what & how
discredited the idea of spontaneous generation theory with the swan neck flask
Who did the swan neck flask experiment
Louis Pasteur
vax's prevent what?
infection disease
In 1796 Edward Jenner
figured out first small pox vaccine
discovered process of vaccination
discovered disease could be prevented through vax w a smaller milder disease causing agent
which came first variolation or vaccination
variolation
variolation started in, & caused
in China 14C
18C Europeans
& BAD reactions
vaccines were developed from
cowpox, better reaction & more immunity
inoculated is another word for
vaccination
1700's ppl thought disease resulted from?
Miasma- bad quality/rotting stuff in environment/air
late 1800's careful scientific inquiry into nature of disease gave right to?
EPIDEMIOLOGY
Epidemiology definition
study of source/cause or mode of transmission of disease
1854 John Snow did what
determined cause of cholera transmission in London
How did John Snow stop the cholera epidemic in London?
removed the handle of the communal water pump & started the sanitary movement
1861 Ignaz Sommelweis determined source of what
puerperal fever or blood poisoning in women during childbirth & kids
How did Ignaz Sommelweis fix the issue?
compared 2 hospitals, encouraged his students to wash hands & fixed the issue
why did ppl wear beak mask/coats?
protect from black plague (specifically the miasma belief)
Louis Pasteur proposed what
that germs cause infectious disease
What did Pasteur prove? (yeast)
that yeast is responsible for fermentation
Who created germ theory & made rabies vax
Pasteur
What did Pasteur do with pasteurization?
It was his technique in heating to kill pathogens
Two most important microbiologists?
Pasteur & Koch
Joseph Lister developed?
practice of antisepsis (chemical disinfection of external living surfaces)
Who used carbolic acid?
Lister, he used the spray during surgery & wounds healed without infection
Who tested on dead animals?
Robert Koch
Robert Koch discovered?
anthrax & tuberculosis & cholera
What did Robert Koch formalize?
standards to equate germs with infection disease
Koch's postulates became criteria for
linking a specific organism to a specific disease
Who developed pure culture techniques?
Koch
Petri dishes + Koch explanation
by adding gelatin to his broth he grew bacterial colonies in a petri dish, but the gelatin liquified at warm temps & digested by bacteria
When & who came up with the agar solution?
1880 Fanny Hesse
bacteriology
the study of bacterial organisms
1873 hansen
leprosy
1886 klebs
diphtheria
1886 fraenkel
pneumonia
1892 welch & nutall
gas gangrene
1898 shiga
dysentery
1906 bordet & gengou
whooping cough/pertussis
1890/ ivanosky & beijerinick
early observation of filterable viruses, tobacco mosaic disease caused by virus
1898 hoof & mouth disease
discovered to be caused by a virus
1901 walter reed
filterable virus causes yellow fever in humans