CBNS116 Hippocampus

Who was a major clue for understanding hippocampal function?

H.M.

What is the relation between the fornix and the hippocampus?

Relays information to and from the hippocampus

What is the hippocampus in the shape of?

Horn

What are the 3 layers of the hippocampus?

Molecular, Pyramidal, Polymorphic

Step 1 of the Hippocampal pathway?

Start at the Entorhinal cortex → Dentate Gyrus

Step 2 of the Hippocampal pathway?

Dentate Gyrus → Mossy Fibers → CA3

Step 3 of the Hippocampal pathway?

CA3 → Schaffer Collaterals → CA1

Step 4 of the Hippocampal pathway?

CA1 → Subiculum

Step 5 of the Hippocampal pathway?

Subiculum → Entorhinal Cortex

What types of cells make up CA1?

Pyramidal

What are the 2 types of glutamate receptors?

AMPA and NMDA

Which channel opens first?

AMPA

Which channel opens second?

NMDA

What is field potential?

There’s a big dip of hyper polarization because the outside is getting more negative as the inside gets more positive

What kind of block, blocks the NMDA receptors?

Mg²⁺

What is the mechanism of synaptic plasticity?

Long term potentiation and Long term depression