refers to the widespread transfer of plants, animals, culture, human populations, technology, and ideas between the Americas and the Old World (Africa, Asia, and Europe) in the 15th and 16th centuries, following Christopher Columbus's arrival in the Caribbean in 1492. This exchange had a profound impact on the world, leading to the introduction of new crops, such as potatoes and tomatoes, to Europe, and the spread of diseases, such as smallpox, to the Americas.