Bordatella pertussis
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8 Terms
B. pertussis transmission
Respiratory droplets
Requires close contact less than 3ft distance
Only reservoir is man
B. pertussis general characteristics
Gram (-) coccobacillus
Strict aerobe
Fastidious
Capsulated
Can grow at 0-10°C taking 3-6 days
Protease +
B. pertussis BCM tests
Oxidase +
Catalase +
Nitrate (-)
Citrate (-)
Urea (-)
B. pertussis virulence factors and structures
Filamentous hemagglutinin and Pertactin - attachment
Toxins
B. pertussis toxins
Adenylate cyclase toxin - antiphagocytic
Lethal/dermonecrotic toxin - inflammatory
Pertussis toxin - mediates colonization and toxemic stages
Tracheal cytotoxin - damages ciliated cells, release of IL-1, inhibits DNA synthesis
B. pertussis Clinical course
3 weeks incubation
0-2nd week: catarrhal stage; contagious px, mild symptoms
2-8th week: paroxysmal stage; whooping cough, PMN necrosis
8-12th week: convalescent stage
B. pertussis culture
Charcoal agar: px coughs directly onto it, or nasopharyngeal swab; bisected pearl appearance
Blood/ Bordet-gengou medium
B. pertussis prevention
DPTHib vax given at 2, 4, 6, and 15-18 months
