Ceutics II Quiz 4
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57 Terms
Gingival epithelium is more permeable than buccal mucosa.
True/False
False
After buccal absorption, drug molecules enter the systemic circulation via lingual veins.
True/False
False
The diameter jejunum varies between the lower limit and the upper limit.
the lower limit: _____
the upper limit: _____
the lower limit ---- 2.5 cm
the upper limit ---- 3.5 cm
For intestinal absorption, the donor compartment is ____ and the acceptor compartment is ____ .
the intestinal lumen; the bloodstream in the capillaries of villi
3 multiple choice options
The sink conditions mean that the concentration in the ____ is negligibly small and approximated as zero.
acceptor compartment
3 multiple choice options
For most drugs, metabolism after buccal absorption is slower than that after GI absorption.
True/False
True
To get from the intestinal lumen into the bloodstream, the drug molecules need to pass about ____ membranes.
30
3 multiple choice options
The apparent partition coefficient of ionizable drugs is calculated as the ____ of the total drug concentrations in the nonpolar and aqueous phases.
ratio
3 multiple choice options
GI motility for the fasted state is characterized by ____ .
cycles of 1 hour quiescence and 1 hour regular activity preceded by a short period of irregular contractions
3 multiple choice options
The normal residence time of food in colon is ____ hours.
20 or more
3 multiple choice options
The epithelium of oral cavity consists of about ____ cell layers.
50
3 multiple choice options
____ has the largest surface area per length unit.
jejunum
3 multiple choice options
The factor qC is the ____ the concentrations of ionized molecules and ion pairs.
ratio of
3 multiple choice options
The absorption rate is the ____ the flux and the area.
product of
3 multiple choice options
Lozenges have a ____ base and dissolve ____ .
hard; slowly
3 multiple choice options
Depression ____ gastric emptying.
slows-down
2 multiple choice options
Ice cream ____ stomach emptying.
slows-down
2 multiple choice options
Select all factors involved in the apparent partition coefficient that account for drug ionization.
the proton factor qH
3 multiple choice options
The factor qH is the ____ the concentrations of ionized and nonionized molecules.
ratio of
3 multiple choice options
The largest increase in the surface area of the small intestine is due to the presence of ____ .
microvilli
3 multiple choice options
Light physical activity ____ gastric emptying.
speeds-up
2 multiple choice options
The diameter of the intestine varies between the lower limit and the upper limit.
the lower limit: ____
the upper limit: _____
the lower limit ---- 2.0 cm
the upper limit ---- 7.0 cm
Select the region(s) of the intestine with the highest permeability for the majority of drugs.
a) colon
b) jejunum
c) ileum
d) duodenum
b) jejunum
d) duodenum
The diameter of ileum varies between the lower limit and the upper limit.
the lower limit: _____
the upper limit: _____
the lower limit ---- 2.0 cm
the upper limit ---- 2.5 cm
Solid meals are processed in stomach for ____ minutes.
15-30
3 multiple choice options
The absorption after bariatric surgery is faster than before the surgery.
True/False
False
The volume of water, if initially larger than 100 mL, is released from the stomach with ____-time course.
exponential
3 multiple choice options
Intake of water ____ gastric emptying.
speeds-up
2 multiple choice options
GI motility for the fed state is characterized by ____ .
regular contractions
3 multiple choice options
Select the statement that is not valid for the pH-partition hypothesis.
ionized species are not transported at all
3 multiple choice options
Select all oral routes that are mainly used for local delivery.
gingival
3 multiple choice options
Select all oral routes that bypass the hepatic first-pass metabolism.
a) sublingual
b) peroral
c) buccal
d) gingival
a) sublingual
c) buccal
d) gingival
Stomach has the blood flow about ____ L/min.
0.15
3 multiple choice options
The longest part of the intestine is ____ .
ileum
3 multiple choice options
Select all factors involved in the apparent partition coefficient that account for drug ion pairing.
the ion-pair factor qC
3 multiple choice options
Lying on the right side ____ gastric emptying.
speeds-up
2 multiple choice options
Vigorous physical exercise ____ gastric emptying.
slows-down
2 multiple choice options
Intake of well-chewed food (particles less than 1 mm) ____ gastric emptying.
speeds-up
2 multiple choice options
The diameter of duodenum varies between the lower limit and the upper limit.
the lower limit: _____
the upper limit: _____
the lower limit ---- 3.0 cm
the upper limit ---- 3.5 cm
Blood flow around small intestine is about ____ L/min.
1
3 multiple choice options
Lying on the left side ____ gastric emptying.
slows-down
2 multiple choice options
Hard, solid food eaten in big chunks ____ gastric emptying.
slows-down
2 multiple choice options
The absorption rate is given in the units of ____ .
mass/time
3 multiple choice options
The apparent partition coefficient of ionizable compounds ____ the pH value of the aqueous phase.
depends in a non-linear way on
3 multiple choice options
The permeability coefficient depends on ____.
a) the partition coefficient of the drug between the lipids of the barrier and the donor compartment medium
b) the distance between the lumen and the bloodstream in the capillaries of villi
c) the diffusion coefficient of the drug in the lumen
d) the thickness of the microvilli
a) the partition coefficient of the drug between the lipids of the barrier and the donor compartment medium
b) the distance between the lumen and the bloodstream in the capillaries of villi
Formation of ion-pairs ____ the value of the apparent partition coefficient.
increases
2 multiple choice options
Normally, the content of stomach is emptied into intestine in ____ hours.
1-2
3 multiple choice options
The apparent partition coefficient depends in a nonlinear way on ____ . Select all factors.
a) the proton factor qH
b) the partition coefficient of ion pairs
c) the ion-pair factor qC
d) the partition coefficient of nonionized molecules
All of the above
Drug molecules need to pass through about ____ bilayers when crossing the epithelium of oral cavity.
500
3 multiple choice options
The most acidic part of the intestine is ____ .
duodenum
3 multiple choice options
The widest part of the intestine is ____ .
colon
3 multiple choice options
After sublingual absorption, drug molecules enter the systemic circulation via lingual veins.
True/False
True
Epithelium of oral cavity is about ____ mm thick.
0.5
3 multiple choice options
Select all gingival dosage forms.
a) slowly dissolving tablets coated with bioadhesive polymers
b) injections
c) ointments
d) qickly dissolving tablets
a) slowly dissolving tablets coated with bioadhesive polymers
b) injections
c) ointments
The normal residence time of food in small intestine is ____ hours
4-5
3 multiple choice options
Stressful emotional state ____ gastric emptying.
speeds-up
2 multiple choice options
For the sink conditions, the flux is the ____ the permeability coefficient and the drug concentration in the donor compartment.
product of
3 multiple choice options
