Immunology (BIOL 318) Lecture 12

Signal transduction

Cytosolic phase of signal transduction

Nuclear phase of signal transduction

SRC family

A family of kinases that phosphorylates the cytosolic side of the receptor

ITAM

• Signalling sequences found on the cytosolic tails of receptors in leukocytes

• Tyrosine based

SYK family

Phosphorylation of ITAMs by SRC family receptors results in the recruitment of ______ in B cells and _______ in T cells

SYK; ZAP70

Adapter proteins

Molecular hubs that physically link different enzymes and promote the assembly of complexes of signaling molecules

Nonreceptor tyrosine kinases

What is a mediator in signal transduction?

Mediator examples

• Various kinases

• Phosphatases

• Ubiquitin

• DNA modifications such as acetylation and methylation