Diuretics - one pager

What class of agents work in the proximal tubule?

SGLT2 inhibitors

What are the side effects of SGLT2 inhibitors?

Hypoglycemia

What are uses for SGLT2 inhibitors?

1. Diabetes

2. Heart failure

3. Block Na-glucose cotransporter

T/F: SGLT2 inhibitors are used for BP control

F

What class of agents work in the thick ascending loop of Henle?

Loop diuretics

What are some example agents that work in the thick ascending loop of henle?

Furosemide
bumetanide

What are some uses of loop diuretics?

1. AKI

2. CKD-related hypertension

3. edema

4. heart failure

5. block Na-K-2 Cl cotransporter

What are some side effects of loop diuretics?

1. Hypokalemia

2. Hypotension

3. Hypomagnesemia

T/F: NSAIDs may decrease the effectiveness of these agents

T

What are some classes of agents that work in the distal tubule?

1. Thiazide diuretics

2. K-sparing diuretics

What is an example of a medication that is a thiazide diuretic?

Hydrochlorothiazide

What are the uses of thiazide diuretics?

1. Hypertension

2. Edema

3. Block Na-K pump in the early distal tubule

What are some side effects of thiazide diuretics?

1. Hypokalemia

2. Hyperglycemia

Which class of diuretics are calcium-sparing

Thiazide

Using this diuretic could increase your risk of AKI when used with NSAIDs

Thiazide

What are some example agents of K-sparing diuretics

1. Spironolactone (any -one)

2. Amiloride

3. Triametrene

what are the uses of amiloride and triametrene ?

1. Hypertension

2. Block NaCl reabsorption

3. Transporter

what are the uses of spironolactone?

1. Heart failure

2. Block aldosterone receptors in late distal tubule

3. CKD

What are the side effects of K-Sparing diuretics?

Hyperkalemia

You would use amiloride and triametrene with what

In combination with a thiazide