Lecture 39 - Long Acting Parenteral Products and Implantables

What are drugs dispersed in polymeric matrices?

Long acting injectable where a polymer forms a solid depot at the injection site

Examples: microspheres, in-situ depot formation, implants

What is Eligard made of?

PLGA polymer dissolved in NMP solvent

example of polymeric depot

How does Eligard work?

After SC injection, NMP diffuses away, PLGA precipitates, and a solid depot forms

drug gets released from gradual PLGA degradation

What is the Eligard mixing system?

Eligard is prefilled/supplied in two separate syringes

One syringe has NMP solvent and polymeric delivery system Atrigel other has leuprolide acetate

The two syringes are joined and are mixed until homogenous then administered SQ

Insulin Pumps advantages?

Few needle sticks

Real time glucose readings

Adjust insulin input based on the side/precise dosing

Insulin pump disadvantages?

Risk of pump/senor error

Risk of skin irritation/infection

Discomfort of having a device on

What is Enhaze?

A technology that helps SQ drug delivery

uses an enzyme to degrade temporarily (HA) in the skin, allowing increased fluid flow/dispersion of drugs

Advantages of Enhanze?

Shorter administration times (mins vs. hours)

No need for administration in hospital/infusion site

Larger delivery volumes compared to standard SQ

Biomaterial?

Is a non-viable material used in a medical device intended to interact with biological systems

Implants?

Are medical devices manufactured to replace a missing biological structure, support a damaged biological structure or enhance an existing biological structure

→ fix/set securely/deeply

What is the Gliadel Wafer?

For treatment of patients with newly diagnosed high grade glioma, as an extra to surgery and radiation

Levonorgestrel releasing implants?

Inhibits the release of luteinizing hormone (LH), a reproductive hormone in ovulation

Long acting reversible BC

99% effective

Matchstick sized device placed under skin lasts up to 5 years

Intrauterine device (IUD)?

Uses hormones are good for 5 years

Copper T version uses copper, a natural sperm killer good for up to 10 years

99% effective

How does the Mirena IUD work?

Inserted into uterus for LABC

Releases progestin, thickening cervical mucus to prevent sperm from reaching/fertilizing an egg

Thins lining of uterus and partially suppresses ovulation

One of 2 hormonal IUDs, other is Skyla, good for 3 years