Psychoactive drug intoxication and withdrawal

What is the MOA of alcohol?

GABA A receptor modulator

What are some intoxication symptoms of alcohol ?

1. Emotional lability

2. Slurred speech

3. Ataxia

4. Coma

5. Black outs

What is the AST VALUE FOR ALCOHOL INTOXICATION?

2 X the ALT value

How do you treat alcohol withdrawal?

Benzodiazepines

How do you treat alcohol intoxication?

Fluids and antiemetics

MOA of barbiturates

GABA A receptor modulator

One key symptom of barbiturates intoxication is :

Respiratory depression

What are the two withdrawal symptoms of barbiturates?

1. Delirium

2. Life threatening cardiovascular collapse

MOA OF BENZODIAZEPINES

Gaba A receptor modulator

Which has a higher safety margin benzo or barbiturates?

Benzodiazepines

Intoxication of benzodiazepines presents with :

1. Ataxia

2. Minor respiratory depression

What’s the antidote of benzodiazepines

Flumazenil

Withdrawal symptoms of benzo:

1. Sleep disturbance

2. Depression

3. Seizures

Opioids MOA:

OPIOID RECEPTOR MODULATOR

What receptors are activated by opioids ?

My

Intoxication of opioids symptoms:

1. Decreased hi motility

2. Respiratory and CNS DEPRESSION

3. Euphoria!!!

4. Low gag reflex

5. Pinpoint pupils

   ***most common drug overdose that causes death

Antidote of opioids

Nola one

Withdrawal symptoms of opioids:

1. Dilated pupils

2. Piloerection

3. Yawning**

4. Rhinorrhea**

5. Lacrimation

How to treat withdrawal symptoms of opioids?

Methadone or buprenorphine

Inhalants cause which type of rash?

Perinatal perioral rash

Effects of inhalants have rapid onset and resolution T/F

TRUE

Inhalants intoxication causes

euphoria , ataxia, slurred speech, disorientation

Inhalants withdrawal causes

Headache, dysphoria, irritability and sleep disturbance