7.3 Glycoconjugates: Proteoglycans and Glycoproteins
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Last updated 12:46 AM on 11/7/22
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7 Terms
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Glycoconjugate
Biologically active molecule made up of an informational carbohydrate joined to a protein or lipid
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What are 2 types of glycoconjugates?
Proteoglycans & glycoproteins
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Proteoglycans
Macromolecules only found at the cell surface or ECM with 1+ sulfated glycosaminoglycan chains
Include the heparan sulfate family
Only has sulfated glycosaminoglycan chains covalently linked to Ser
Include the heparan sulfate family
Only has sulfated glycosaminoglycan chains covalently linked to Ser
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Proteoglycan unit
Core protein with covalently attached glycosaminoglycans Tetrasaccharide linker connects to glycosaminoglycan to a Ser residue of the protein
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What are 2 families of membrane heparan sulfate proteoglycans?
Syndecans and glypicans
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Syndecans
Single transmembrane domain and an extracellular domain bearing 3-5 chains of heparan sulfate and chondroitin sulfate
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Glypicans
Attached to the membrane by a GPI anchor (a glycosylated derivative of the membrane lipid phosphatidylinositol
Note 
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