Sympathetic drugs - Sympatholytics

Sympatholytics:

a. Antagonists of sympathetic receptors

b. Prevent or reverse the actions of endogenously released NE or EPI or exogenously administered sympathomimetic agents

c. Classifications include direct acting and peripheral acting

d. a and b

e. b and c

f. All

f. All

1) Direct acting sympatholytics are alpha and beta blockers

2) Peripherally-acting sympatholytics are adrenergic neuronal blockers

a. Only 1 is true

b. Only 2 is true

c. Both true

d. Both false

c. Both true

Describe peripherally-acting sympatholytics except:

a. Adrenergic Neuronal Blockers

b. Drug that inhibit the normal physiologic release of norepinephrine

c. Inhibits the storage vesicle of NE

d. Inhibit the exocytosis NE

e. None

e. None

Alpha Blockers:

a. Predominantly affect CV increasing PVR and BP

b. Convert the pressor action of sympathomimetics to a depressor response known as epinephrine reversal

c. Both

d. None

b.

Alpha Blockers:

a) Predominantly affect CV LOWERING PVR and BP

b) Convert the pressor action of sympathomimetics to a depressor response known as epinephrine reversal

Non-selective alpha blockers.

I. Phenoxybenzamine

II. Phentolamine

III. Prazosin

IV. Doxazosin

V. Terazosin

VI. Alfuzosin

VII. Tamsulosin

VIII. Yohimbine

IX. Rauwolscine

a. I, II

b. I

c. III, IV

d. III, IV, V, VI, VII

e. VIII, IX

f. IX

a. I, II

Selective alpha1 blockers.

I. Phenoxybenzamine

II. Phentolamine

III. Prazosin

IV. Doxazosin

V. Terazosin

VI. Alfuzosin

VII. Tamsulosin

VIII. Yohimbine

IX. Rauwolscine

a. I, II

b. I

c. III, IV

d. III, IV, V, VI, VII

e. VIII, IX

f. IX

d. III, IV, V, VI, VII

Selective alpha2 blockers.

I. Phenoxybenzamine

II. Phentolamine

III. Prazosin

IV. Doxazosin

V. Terazosin

VI. Alfuzosin

VII. Tamsulosin

VIII. Yohimbine

IX. Rauwolscine

a. I, II

b. I

c. III, IV

d. III, IV, V, VI, VII

e. VIII, IX

f. IX

e. VIII, IX

Reversible and competitive non-selective alpha blockers.

a. Phenoxybenzamine

b. Phentolamine

b. Phentolamine

Irreversible and noncompetitive non-selective alpha blockers.

a. Phenoxybenzamine

b. Phentolamine

a. Phenoxybenzamine

For HTN and symptomatic relief of urinary retention in BPH patients.

a. Alpha blockers in general

b. Selective alpha1 blockers in general

c. Phentolamine

d. Phenoxybenzamine

e. Phentolamine and Phenoxybenzamine

f. Tamsulosin

a. Alpha blockers in general

For hypertension in patient with pheochromocytoma.

a. Alpha blockers in general

b. Selective alpha1 blockers in general

c. Phentolamine

d. Phenoxybenzamine

e. Phentolamine and Phenoxybenzamine

f. Tamsulosin

e. Phentolamine and Phenoxybenzamine

For essential HTN.

a. Alpha blockers in general

b. Selective alpha1 blockers in general

c. Phentolamine

d. Phenoxybenzamine

e. Phentolamine and Phenoxybenzamine

f. Prasozin

f. Prasozin

For urinary obstruction in BPH patients.

a. Alpha blockers in general

b. Selective alpha1 blockers in general

c. Phentolamine

d. Phenoxybenzamine

e. Phentolamine and Phenoxybenzamine

f. Tamsulosin

b. Selective alpha1 blockers in general

Greater efficacy for urinary obstruction in BPH patients.

a. Alpha blockers in general

b. Selective alpha1 blockers in general

c. Phentolamine

d. Phenoxybenzamine

e. Phentolamine and Phenoxybenzamine

f. Tamsulosin

f. Tamsulosin

For reversible peripheral vasospasm (Raynaud syndrome) and erectile dysfunction

a. Alpha blockers in general

b. Selective alpha1 blockers in general

c. Phentolamine

d. Phenoxybenzamine

e. Phentolamine and Phenoxybenzamine

f. Tamsulosin

c. Phentolamine

Adverse effects of phentolamine except:

a. postural or orthostatic hypotension

b. reflex tachycardia

c. arrhythmia

d. angina

e. diarrhea

f. none

f. none

Adverse effects of Prazosin, Terazosin, Doxazosin.

a. Has initial effect of postural hypotension

b. Do not produce significant tachycardia

c. Both

d. None

c. Both

Beta1 blockers:

a. Lowers blood pressure

b. Reduced cardiac inotropy, chronotropy, and

dromotropy

c. RAAS inhibition: reduced renin release

d. a and b

e. b and c

f. All

f. All

Increased airway resistance.

a. Beta1 blockers

b. Beta2 blockers

c. Alpha1 blockers

d. Alpha2 blockers

b. Beta2 blockers

General effects of beta blockers except:

a. Decreased IOP

b. Inhibit lipolysis

c. Inhibit glycogenolysis

d. Decrease HDL

e. Local anesthetic action

f. None

f. None

Nonselective beta blockers except:

a. Nadolol

b. Sotalol

c. Timolol

d. Propranolol

e. Atenolol

f. None

e. Atenolol - this is BETA1 selective

Selective beta1 blocker except:

Bisoprolol

Esmolol

Betaxolol

Atenolol

Metoprolol

Acebutolol

a. Betaxolol

b. Metoprolol

c. Acetbutolol

d. Bisoprolol

e. None

e. None

Selective beta2 blocker:

a. Butoxamine

b. Metoprolol

c. Acetbutolol

d. Bisoprolol

e. Propranolol

a. Butoxamine

Butoxamine has a good therapeutic application

a. True

b. False

b. False

Butoxamine is selective beta2 blocker which do not have therapeutic application.

B-blockers with intrinsic sympathomimetic activity.

I. Acebutolol

II. Pindolol

III. Labetalol

IV. Carvedilol

V. Propranolol

a. I, II, III, IV

b. II, III

c. III, IV

d. I, III, V

e. I, II, III

e. I, II, III

Beta Blocker with ISA (Beta 2 Agonism): CLAP

• Carteolol, Celiprolol

• Labetalol

• Acebutolol

• Pindolol, Penbutolol

B-blockers with local anesthesia — membrane stabilizing effect.

I. Acebutolol

II. Pindolol

III. Labetalol

IV. Carvedilol

V. Propranolol

a. I, II, III, IV

b. II, III

c. III, IV

d. I, II, III, V

e. I, II, III

d. I, III, V

B-blockers with local anesthesia — membrane stabilizing effect: PALM

• Propranolol, Pindolol

• Acebutolol

• Labetalol

• Metoprolol

B-blockers that are vasodilator through alpha 1 blockade:

I. Acebutolol

II. Pindolol

III. Labetalol

IV. Carvedilol

V. Propranolol

a. I, II, III, IV

b. II, III

c. III, IV

d. I, III, V

e. I, II, III

c. III, IV

Beta blockers with alpha 1 blockade:

• Carvedilol

• Labetalol

Beta blocker that enhanced NO level thus acting as vasodilator.

a. Acebutolol

b. Pindolol

c. Labetalol

d. Carvedilol

e. Propranolol

f. Nevibolol

f. Nevibolol

Cardio selective

a. Selective beta1 blocker

b. Selective beta2 blocker

c. Nonselective beta blocker

a. Selective beta1 blocker

Contraindicated with bronchial asthma due to enhance resistance.

a. Selective beta1 blocker

b. Selective beta2 blocker

c. Nonselective beta blocker

d. a and b

e. b and c

e. b and c

Therapeutic uses of beta blockers in the CVS except:

a. Generally, for HTN, in combination with a diuretic or vasodilator

b. Reduce incidence of MI thus used as anti anginal

c. Prophylaxis for Supraventricular Tachycardia (SVT) and Ventricular Tachycardia (VT)

d. Prophylaxis for angina pectoris

e. None

e. None

Beta blockers are the first line agent for hypertension in patients with history of myocardial infarction. They should be used in combination with

a. Vitamins

b. Diuretics

c. Vasodilators

d. b and c

e. a and b

f. All

d. b and c

Beta blockers used prophylaxis for angina pectoris:

a. Timolol

b. Propranolol

c. Metoprolol

d. a and b

e. b and c

f. All

f. All

Approved beta blockers for treatment of CHF except:

a. Carvedilol

b. Bisoprolol

c. Metoprolol tartrate

d. Nevibolol

e. None

c. Metoprolol tartrate

4 Approved beta blockers for treatment of CHF:

a) Carvedilol

b) Bisoprolol

c) Metoprolol SUCCINATE

d) Nevibolol

Beta blockers that is not contraindicated to patients with CHF and in fact approved for its treatment.

a. Carvedilol

b. Bisoprolol

c. Metoprolol succinate

d. Nevibolol

e. All

f. None

e. All

The most cardio selective beta blockers which also causes vasodilation due to enhanced level of nitric oxide.

a. Carvedilol

b. Bisoprolol

c. Metoprolol tartrate

d. Nevibolol

d. Nevibolol

Beta blockers used for glaucoma.

a. Timolol

b. Propranolol

c. Betaxolol

d. a and b

e. a and c

f. All

e. a and c

Propranolol:

a. For sympathetic symptoms of hyperthyroidism

b. Prophylaxis of migraine HA

c. Treatment of stage fright

d. a and b

e. b and c

f. All

All

Propranolol:

a) For sympathetic symptoms of hyperthyroidism

b) Prophylaxis of migraine HA

c) Treatment of stage fright

Beta blockers adverse effects

a. Majority may precipitate HF in patients with preexisting compromised cardiac function

b. Mask tachycardia associated with hypoglycemia

c. Mask the signs of developing hyperthyroidism

d. a and b

e. b and c

f. All

f. All

May cause bronchoconstriction

Contraindicated in patients with bronchial asthma and COPD

a. Selective B1 blocker

b. Selective B2 blocker

c. Nonselective B blocker

c. Nonselective B blocker

Propranolol adverse effects except:

a. Sedation

b. Sleep disturbances

c. Depression

d. None

e. All

d. None

Peripherally acting sympatholytics or adrenergic neuronal blockers except:

a. Reserpine

b. Guanethedine

c. Guanadrel

d. Bretylium

e. None

e. None

Inhibits storage of DA.

a. Reserpine

b. Guanethedine

c. Guanadrel

d. Bretylium

e. None

a. Reserpine

Inhibit exocytosis of NE except:

a. Reserpine

b. Guanethedine

c. Guanadrel

d. Bretylium

e. None

a. Reserpine