Anxiety Drugs ONLY

BZDs

MOA: Enhance inhibitory effects of GABA by binding to allosteric site on GABA-A = increase affinity of GABA binding = increase frequency of chloride channel opening

Short acting (1-15 hr)

• Triazolam

• Midazolam

Immediate-acting (15-20 hr) “A LOT”

• Alprazolam (Xanax)

• Oxazepam

• Lorazepam (Ativan)

• Temazepam (Restoril)

Long-acting (>20 hrs) 3CDF

• Chlordiazepoxide

• Clonazepam (Klonopin)

• Diazepam (Valium)

• Flurazepam

• Clorazepate (Tranxene-T)

BZD Antidote

Flumazenil (Romazicon)

• MOA: competitive GABA receptor antagonist

Non-BZD

Buspirone (Buspar)

• MOA: may be due to affinity for 5-HT1A and 5-HT2 receptors

Propranolol

• MOA: competitive non-selective beta-1 and beta-2 adrenergic receptor blocker

Beta blocker

Propranolol

• MOA: competitive non-selective beta-1 and beta-2 adrenergic receptor blocker

  • physical symptoms only